| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-03-22 |
| タイトル |
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|
タイトル |
Thromboxane A(2) and prostaglandin F-2 alpha mediate inflammatory tachycardia |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
牛首, 文隆
Takayama, K
Yuhki, K
Ono, K
Fujino, T
Hara, A
Yamada, T
Kuriyama, S
Karibe, H
Okada, Y
Takahata, O
Taniguchi, T
Iijima, T
Iwasaki, H
Narumiya, S
|
| 著者 ローマ字 |
|
|
|
Ushikubi, Fumitaka |
| 書誌情報 |
NATURE MEDICINE
巻 11,
号 5,
p. 562-566,
発行日 2005-05-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1078-8956 |
| DOI |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1038/nm1231 |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://www.nature.com/nm/journal/v11/n5/full/nm1231.html | http://www.nature.com/nm/journal/v11/n5/full/nm1231.html |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Systemic inflammation induces various adaptive responses including tachycardia. Although inflammation-associated tachycardia has been thought to result from increased sympathetic discharge caused by inflammatory signals of the immune system^1, definitive proof has been lacking. Prostanoids-including prostaglandin (PG) D_2, PGE_2, PGF_<2α>, PGI_2, and thromboxane (TX) A_2-exert their actions through specific receptors: DP, EP (EP_1, EP_2, EP_3, EP_4), FP, IP, and TP, respectively^2. Here we have examined the roles of prostanoids in inflammatory tachycardia with the use of mice lacking each of these receptors individually. The TXA_2 analog I-BOP and PGF_<2α> each increased the beating rate of the isolated atrium of wild-type (WT) mice in vitro through interaction with TP and FP, respectively. The cytokine-induced increase in beating rate was markedly inhibited in atria from mice lacking either TP or FP. The tachycardia induced in WT mice by injection of lipopolysaccharide (LPS) was greatly attenuated in TP-/- or FP-/- mice and was completely absent in mice lacking both TP and FP. Propranolol failed to block the LPS-induced increase in heart rate in WT animals. Our results show that inflammatory tachycardia is caused by a direct action on the heart of TXA_2 and PGF_<2α> formed under systemic inflammatory conditions. |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
author |
| 資源タイプ |
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|
内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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|
出版タイプ |
AM |
| フォーマット |
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|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
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|
15834430 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
1089 |
377.pdf (1.2 MB)
