| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-03-22 |
| タイトル |
|
|
タイトル |
Decreases in pheromonal responses at the accessory olfactory bulb of mice with a deficiency of the alpha(1B) or beta 3-subunits of voltage-dependent Ca2+-channels |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
柏柳, 誠
Murakami, M
Matsui, H
Shiraiwa, T
Sasano, H
Takahashi, E
|
| 著者 ローマ字 |
|
|
|
Kashiwayanagi, Makoto |
| 書誌情報 |
BIOLOGICAL & PHARMACEUTICAL BULLETIN
巻 29,
号 3,
p. 437-442,
発行日 2006-03-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0918-6158 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Pheromones affect gonadal functions and sexual behaviors. Information in regard to pheromones is received by the vomeronasal organ (VNO) and transmitted to the accessory olfactory bulb (AOB). We investigated the physiological role of the α1B and β3 subunits of the N (neuronal)-type voltage-dependent Ca2+ channel in the neurotransduction in the accessory olfactory (vomeronasal) system using α1B-deficient mice and β3-deficient mice. RT-PCR studies showed the existence of β1, β2, β3, β4, α1A, α1B, and α1C subunits of voltage-dependent Ca2+ channels in the mouse VNO. Immunohistochemical studies showed that the α1A, α1B, and α1C subunits of voltage-dependent Ca2+ channels exist in the sensory neurons and supporting cells of the mouse VNO. Exposure of the VNO to urine samples excreted from male mice induced lower Fos-immunoreactivity in the periglomerular (PG) cells of the AOBs in α1B-deficient female mice than in those of wild mice. The density of Fos-immunoreactive (Fos-ir) cells after exposure to female urine samples at the periglomerular cell layer of α1B-deficient male mice was lower than that of wild mice. Exposure of the VNO of β3-deficient female mice to male urine samples also induced low Fos-ir cells in the periglomerular cell layer of the AOB. These data suggest the importance of the α1B and β3 subunits of the Ν−type voltage-dependent Ca2+ channel for the pheromone signal transduction system.Keywords: N-type Ca2+ channel, α1B subunit, β3 subunit, accessory olfactory bulb, pheromonal response |
| 注記 |
|
|
内容記述タイプ |
Other |
|
注記 |
author |
| 資源タイプ |
|
|
内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
|
|
出版タイプ |
AM |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
|
|
|
KASHI3010 |
| 閲覧数(XooNIps) |
|
| ダウンロード数(XooNIps) |
|
|
|
1188 |
374.pdf (596.4 kB)
