| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-03-22 |
| タイトル |
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タイトル |
Antiepileptic effect of nefiracetam on kainic acid-induced limbic seizure in rats |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ |
journal article |
| 著者 |
橋詰, 清隆
Kunimoto, M
Maeda, T
Tanaka, T
|
| 著者 ローマ字 |
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|
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Hashizume, Kiyotaka |
| 書誌情報 |
EPILEPSY RESEARCH
巻 39,
号 3,
p. 221-228,
発行日 2000-05-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0920-1211 |
| DOI |
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関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1016/S0920-1211(00)00099-1 |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://www.sciencedirect.com/science/journal/09201211 | http://www.sciencedirect.com/science/journal/09201211 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Nefiracetam is being studied as a novel cognition-enhancing agent; however, it has been suggested from studying its chemical structure that it has a potential anticonvulsive effect. We examined the antiepileptic effect of nefiracetam on kainic acid (KA)-induced seizures. KA was infused into the left basolateral amygdaloid nucleus, and focal limbic seizures were induced in 43 male Wistar rats. During status epilepticus, 10, 50, 100 or 200 mg/kg of nefiracetam was intravenously injected. Nefiracetam inhibited KA-induced limbic seizures at doses over 100 mg/kg while it had a sedative effect on the animals. In [14C] deoxyglucose autoradiographic studies, the propagation of seizure-induced hypermetabolic areas was also suppressed dose-dependently. From the results, it was indicated that nefiracetam has an antiepileptic effect and that its application may suppress seizure propagation. Further study is required whether this agent is available as a novel anticonvulsant. |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
ELSEVIER, Hashizume, K; Kunimoto, M; Maeda, T; Tanaka, T, S, EPILEPSY RESEARCH, 39(3), 221-228, 2000.
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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10771248 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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2110 |
360.pdf (709.1 kB)
