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Antiepileptic effect of nefiracetam on kainic acid-induced limbic seizure in rats

https://asahikawa-med.repo.nii.ac.jp/records/295
https://asahikawa-med.repo.nii.ac.jp/records/295
06a94a6c-1d0c-4c20-b096-cd1e32a43d1f
名前 / ファイル ライセンス アクション
360.pdf 360.pdf (709.1 kB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2007-03-22
タイトル
タイトル Antiepileptic effect of nefiracetam on kainic acid-induced limbic seizure in rats
言語 en
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 橋詰, 清隆

× 橋詰, 清隆

橋詰, 清隆

ja-Kana ハシヅメ, キヨタカ

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Kunimoto, M

× Kunimoto, M

Kunimoto, M

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Maeda, T

× Maeda, T

Maeda, T

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Tanaka, T

× Tanaka, T

Tanaka, T

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著者 ローマ字
Hashizume, Kiyotaka
書誌情報 EPILEPSY RESEARCH

巻 39, 号 3, p. 221-228, 発行日 2000-05-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 0920-1211
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1016/S0920-1211(00)00099-1
リンクURL
内容記述タイプ Other
内容記述 http://www.sciencedirect.com/science/journal/09201211 | http://www.sciencedirect.com/science/journal/09201211
抄録
内容記述タイプ Abstract
内容記述 Nefiracetam is being studied as a novel cognition-enhancing agent; however, it has been suggested from studying its chemical structure that it has a potential anticonvulsive effect. We examined the antiepileptic effect of nefiracetam on kainic acid (KA)-induced seizures. KA was infused into the left basolateral amygdaloid nucleus, and focal limbic seizures were induced in 43 male Wistar rats. During status epilepticus, 10, 50, 100 or 200 mg/kg of nefiracetam was intravenously injected. Nefiracetam inhibited KA-induced limbic seizures at doses over 100 mg/kg while it had a sedative effect on the animals. In [14C] deoxyglucose autoradiographic studies, the propagation of seizure-induced hypermetabolic areas was also suppressed dose-dependently. From the results, it was indicated that nefiracetam has an antiepileptic effect and that its application may suppress seizure propagation. Further study is required whether this agent is available as a novel anticonvulsant.
注記
内容記述タイプ Other
注記 ELSEVIER, Hashizume, K; Kunimoto, M; Maeda, T; Tanaka, T, S, EPILEPSY RESEARCH, 39(3), 221-228, 2000.
\nauthor
資源タイプ
内容記述タイプ Other
資源タイプ text
著者版フラグ
出版タイプ AM
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内容記述タイプ Other
内容記述 application/pdf
ID(XooNIps)
10771248
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2110
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Cite as

橋詰, 清隆, Kunimoto, M, Maeda, T, Tanaka, T, n.d., Antiepileptic effect of nefiracetam on kainic acid-induced limbic seizure in rats: 221–228 p.

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