| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2010-08-02 |
| タイトル |
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タイトル |
Orexinergic projections to the cat midbrain mediate alternation of emotional behavioural states from locomotion to cataplexy |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| その他（別言語等）のタイトル |
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その他のタイトル |
Orexinergic projections to the midbrain mediate alternation of emotional behavioral states from locomotion to cataplexy |
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言語 |
en |
| 著者 |
高草木, 薫
Takahashi, K
Saito, K
Harada, H
Okumura, T
Kayama, Y
Koyama, Y
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| 著者 ローマ字 |
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Takakusaki, Kaoru |
| 著者 ローマ字 |
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en |
| 書誌情報 |
Journal of Physiology
巻 568,
号 3,
p. 1003-1020,
発行日 2005-11-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0022-3751 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1113/jphysiol.2005.085829 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://dx.doi.org/10.1113/jphysiol.2005.085829 | http://dx.doi.org/10.1113/jphysiol.2005.085829 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Orexinergic neurones in the perifornical lateral hypothalamus project to structures of the midbrain, including the substantia nigra and the mesopontine tegmentum. These areas contain the mesencephalic locomotor region (MLR), and the pedunculopontine and laterodorsal tegmental nuclei (PPN/LDT), which regulate atonia during rapid eye movement (REM) sleep. Deficiencies of the orexinergic system result in narcolepsy, suggesting that these projections are concerned with switching between locomotor movements and muscular atonia. The present study characterizes the role of these orexinergic projections to the midbrain. In decerebrate cats, injecting orexin-A (60 μm to 1.0 mm, 0.20?0.25 μl) into the MLR reduced the intensity of the electrical stimulation required to induce locomotion on a treadmill (4 cats) or even elicit locomotor movements without electrical stimulation (2 cats). On the other hand, when orexin was injected into either the PPN (8 cats) or the substantia nigra pars reticulata (SNr, 4 cats), an increased stimulus intensity at the PPN was required to induce muscle atonia. The effects of orexin on the PPN and the SNr were reversed by subsequently injecting bicuculline (5 mm, 0.20?0.25 μl), a GABAA receptor antagonist, into the PPN. These findings indicate that excitatory orexinergic drive could maintain a higher level of locomotor activity by increasing the excitability of neurones in the MLR, while enhancing GABAergic effects on presumably cholinergic PPN neurones, to suppress muscle atonia. We conclude that orexinergic projections from the hypothalamus to the midbrain play an important role in regulating motor behaviour and controlling postural muscle tone and locomotor movements when awake and during sleep. Furthermore, as the excitability is attenuated in the absence of orexin, signals to the midbrain may induce locomotor behaviour when the orexinergic system functions normally but elicit atonia or narcolepsy when the orexinergic function is disturbed. |
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言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
The definitive version is available at www.blackwell-synergy.com and www.jphysiol.org. |
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言語 |
en |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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16123113 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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790 |
3133.pdf (7.9 MB)
