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Extracellular environment and extracellular serine proteases in the central nervous system
https://asahikawa-med.repo.nii.ac.jp/records/2284
https://asahikawa-med.repo.nii.ac.jp/records/22840ad6b5b5-5efd-40c4-bd53-7fec3d57ff94
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
3130.pdf (31.1 MB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||
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| 公開日 | 2010-08-02 | |||||||||
| タイトル | ||||||||||
| タイトル | Extracellular environment and extracellular serine proteases in the central nervous system | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
吉田, 成孝
× 吉田, 成孝
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| 著者 ローマ字 | ||||||||||
| Yoshida, Shigetaka | ||||||||||
| 著者 ローマ字 | ||||||||||
| en | ||||||||||
| 書誌情報 |
Connective Tissue 巻 35, 号 1, p. 37-43, 発行日 2003-03-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0916-572X | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Extracellular serine proteases play important roles in the central nervous system (CNS) by modifying extracellular environments. Prothrombin is expressed in the CNS and thrombin has been shown to have inhibitory function on neurite extension, however, its physiological function is not fully understood. Tissue plasminogen activators (tPA) has important function on neural plasticity in ocular dominance and long-term potentiation (LTP). tPA also has crucial function in the excitotoxic neuronal cell death through the activation of plasminogen. Beyond these proteases, several kallikrein family proteases including neuropsin and protease M are expressed in the CNS. Neuropsin is mainly expressed in the neurons of the limbic system and has important in the neural plasticity such as LTP and kindling. Following injury, neuropsin is induced in oligodendrocytes and may be related to demyelination. Protease M is constitutively expressed in oligodendrocytes and may have scavenging function. Other kallikrein family proteases are expressed in the CNS but their functions remained to be clarified. | |||||||||
| 言語 | en | |||||||||
| 資源タイプ | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 資源タイプ | text | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
| ID(XooNIps) | ||||||||||
| Yoshi-6610 | ||||||||||
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| ダウンロード数(XooNIps) | ||||||||||
| 525 | ||||||||||
