| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2010-06-30 |
| タイトル |
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タイトル |
Ah receptor, CYP1A1, CYP1A2 and CYP1B1 gene polymorphisms are not involved in the risk of recurrent pregnancy loss |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
西條, 泰明
Sata, Y
Yamada, H
Suzuki, K
Sasaki, S
Kondo, T
Gong, Y
Kato, EH
Shimada, S
Morikawa, M
Minakami, H
Kishi, R
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| 著者 ローマ字 |
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Saijo, Yasuaki |
| 著者 ローマ字 |
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en |
| 書誌情報 |
Molecular Human Reproduction
巻 10,
号 10,
p. 729-733,
発行日 2004-10-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1360-9947 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1093/molehr/gah096 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://dx.doi.org/10.1093/molehr/gah096 | http://dx.doi.org/10.1093/molehr/gah096 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The etiology of recurrent pregnancy loss (RPL) remains unclear, but it may be related to a possible genetic predisposition together with involvement of environmental factors. We examined the relation between RPL and polymorphisms in four genes, human aryl hydrocarbon (Ah) receptor, cytochrome P450 (CYP) 1A1, CYP1A2 and CYP1B1, which are involved in the metabolism of a wide range of environmental toxins and carcinogens. All cases and controls were women resident in Sapporo, Japan and the surrounding area. The Ah receptor, CYP1A1, CYP1A2 and CYP1B1 genotypes were assessed in 113 Japanese women with recurrent pregnancy loss (RPL) and 203 ethnically matched women experiencing at least one live birth and no spontaneous abortion (control). No significant differences in Ah receptor, CYP1A1, CYP1A2 and CYP1B1 genotype frequencies were found between the women with RPL and the controls [Ah receptor: Arg/Arg (reference); Arg/Lys and Lys/Lys, odds ratio (OR)=0.67; 95% confidence interval (CI)=0.40?1.11, CYP1A1: m1m1 (reference); m1m2 and m2m2, OR = 0.86; 95% CI = 0.53-1.40, CYP1A2: C/C and C/A (reference); A/A, OR = 1.16; 95% CI = 0.71-1.88, CYP1B1: Leu/Leu (reference); Leu/Val and Val/Val, OR = 1.18; 95% CI = 0.68?2.02]. The present study suggests that the Ah receptor, CYP1A1, CYP1A2 and CYP1B1 gene polymorphisms are not major genetic regulators in RPL. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Biochemistry following peer review. The definitive publisher-authenticated version Saijo, Y. ; Sata, F. ; Yamada, H. ; Suzuki, K. ; Sasaki, S. ; Kondo, T. ; Gong, Y. ; Kato, EH. ; Shimada, S. ; Morikawa, M. ; Minakami, H. ; Kishi, R., MHR: Basic science of reprod. Medicine, 10(10), 2004, 729-733 is available online at: http://molehr.oxfordjournals.org/cgi/content/abstract/10/10/729. |
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言語 |
en |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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15299091 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1351 |
3089.pdf (435.3 kB)
