| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2010-06-30 |
| タイトル |
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タイトル |
An EP4 receptor agonist prevents indomethacin-induced closure of rat ductus arteriosus in vivo |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
梶野, 浩樹
Taniguchi, T
Fujieda, K
Ushikubi, F
Muramatsu, I
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| 著者 ローマ字 |
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Kajino, Hiroki |
| 著者 ローマ字 |
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en |
| 書誌情報 |
Pediatric Research
巻 56,
号 4,
p. 586-590,
発行日 2004-10-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0031-3998 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://journals.lww.com/pedresearch/pages/default.aspx | http://journals.lww.com/pedresearch/pages/default.aspx |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Indomethacin exerts a strong tocolytic effect by suppressing uterine contractions mediated by prostaglandins. However, indomethacin also induces in utero closure of fetal ductus arteriosus (DA), leading to serious neonatal consequences. Using rats, we tested the effect of an agonist for a subtype of prostaglandin E2 receptor (EP4), ONO-AE1-437 and its prodrug ONO-4819, as a DA dilator during indomethacin treatment. In vitro, ONO-AE1-437 exhibited a potent dilatory effect on DA against O_2^- and indomethacin-induced contractions in a concentration-dependent manner. In vivo, rat dams were given indomethacin (10 mg/kg, p.o.) alone or with ONO-4819 (0.3 μg/kg/h, s.c.) on d 21 of gestation and pups were delivered 4 h later through cesarean section to evaluate the ratio of diameter of DA to that of pulmonary artery. Pups from dams with no drug had DA/PA ratio of 0.9 ± 0.05, whereas those from dams with indomethacin alone had a decreased ratio of 0.2 ± 0.03. When ONO-4819 was co-administered to the dams, the ratio recovered significantly to 0.7 ± 0.06. The administration of ONO-4819 to the dams did not induce any increase in the uterine activity. These results suggest that administration of an EP4 agonist in addition to indomethacin might prevent adverse reactions of indomethacin on fetal DA without restricting its tocolytic effects. |
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言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
This is a non-final version of an article published in final form in Kajino, Hiroki ; Taniguchi, Takanobu ; Fujieda, Kenji ; Ushikubi, Fumitaka ; Muramatsu, Ikunobu, An EP4 receptor agonist prevents indomethacin-induced closure of rat ductus arteriosus in vivo, Pediatric Research 54(6), OCT 2004, pp. 586-590. |
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言語 |
en |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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15295094 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1557 |
3083.pdf (606.9 kB)
