| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-02-27 |
| タイトル |
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タイトル |
Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
清水, 恵子
Matsubara, K
Ohtaki, K
Shiono, H
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| 著者 ローマ字 |
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|
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Shimizu, Keiko |
| 書誌情報 |
NEUROSCIENCE RESEARCH
巻 46,
号 4,
p. 523-532,
発行日 2003-08-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0168-0102 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/S0168-0102(03)00163-9 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.sciencedirect.com/science/journal/01680102 | http://www.sciencedirect.com/science/journal/01680102 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Paraquat (PQ) is a herbicide to possibly induce Parkinson's disease (PD), since a strong correlation has been found between the incidence of the disease and the amount of paraquat used. In this study, we examined PQ toxicity in rat organotypic midbrain slice cultures. PQ dose dependently reduced the number of dopaminergic neurons in cultured slices. Since this damage was prevented by GBR-12909, the dopamine transporter could be an initial step of the PQ induced dopaminergic neurotoxicity. The sequential treatments with lower PQ and MPP+ doses, where each dose alone was not lethal, markedly killed dopamine neurons, suggesting that the exposure of a lower dose of PQ could lead to the vulnerability of dopaminergic neurons. This cell death was prevented by the inhibitors of NMDA, nitric oxide synthase (NOS), cycloheximide and caspase cascade. Neurons expressing NOS were identified inside and around the regions where dopamine neurons were packed. The cell death induced by the sequential treatments with PQ and MPP+ was also rescued by L-deprenyl and dopamine D2/3 agonists. These results strongly support that the constant exposure to low levels of PQ would lead to the vulnerability of dopaminergic neurons in the nigrostriatal system by the excitotoxic pathway, and might potentiate neurodegeneration caused by the exposure of other substances and aging. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
ELSEVIER, Shimizu, K; Matsubara, K; Ohtaki, K; Shiono, H, NEUROSCIENCE RESEARCH, 46(4), 523-532, 2003.
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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12871774 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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953 |
254.pdf (664.0 kB)
