| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-02-27 |
| タイトル |
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タイトル |
An adenosine agonist regulates outward active transport of fluorescein across rabbit blood retinal barrier |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
河原, 温
Hikichi, T
Kitaya, N
Takahashi, J
Mori, F
Yoshida, A
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| 著者 ローマ字 |
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Kawahara, Atsushi |
| 書誌情報 |
EXPERIMENTAL EYE RESEARCH
巻 80,
号 4,
p. 493-499,
発行日 2005-04-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0014-4835 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.exer.2004.10.013 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.sciencedirect.com/science/journal/00144835 | http://www.sciencedirect.com/science/journal/00144835 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
PURPOSE. To investigate the regulation of an adenosine agonist, 2-5’-N-ethylcarboxamidoadenosine (NECA) on the outward active transport of fluorescein across rabbit blood retinal barrier (BRB).METHODS. Pigmented rabbits were given an intravitreous injection of various concentrartions of NECA or phosphate buffered saline (PBS). Sodium fluorescein was intravenously injected 180 minutes after NECA injection. Differential vitreous fluorophotometry (DVF) was performed 180 minutes after intravenous injection of sodium fluorescein to measure fluorescein (F) and fluorescein monoglucuronide (FG) concentrations in the vitreous. The F/FG ratio was calculated as an indicator of the estimated outward active transport of the BRB. Retinal detachments were experimentally produced by injection of PBS into the subretinal space. Experimental solution or PBS were injected intravitreally, and the size of blebs was monitored under masked conditions.RESULTS. In eyes with intravitreal injection of high dose NECA, F/FG ratio was significantly lower when compared with in controls (p<0.05), but in eyes with low dose injection that was higher (p<0.05). The effect of high dose NECA on F/FG ratio was suppressed by the A1 receptor antagonist, 8-cyclopentyl-1, 3-dipropylxanthine (CPX) and the effect of low dose NECA was suppressed by the A2 receptor antagonist, ZM241385. The A3 receptor antagonist MRS1191 didn’t have an influence on the effect of high or low dose NECA. Intravitrteal injection of high dose NECA enhanced the removal of subretinal fluid when compared with intravitrteal injection of PBS alone. CONCLUSIONS. These data suggest that intravitreous injection of high dose NECA accelerate the active outward transport of the BRB via A1 receptors and low dose NECA decelerate it via A2 receptors, and A3 receptors don’t contribute to the regulation of it. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
ACADEMIC PRESS, Kawahara, A; Hikichi, T; Kitaya, N; Takahashi, J; Mori, F; Yoshida, A, EXPERIMENTAL EYE RESEARCH, 80(4), 493-499, 2005.
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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15781276 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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4718 |
251.pdf (507.8 kB)
