| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2010-02-01 |
| タイトル |
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タイトル |
Transforming growth factor-β1 induces matrix metalloproteinase-9 expression in human meningeal cells via ERK and Smad pathways |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
岡本, 年男
Takahashi, S
Nakamura, E
Nagaya, K
Hayashi, T
Fujieda, K
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| 著者 ローマ字 |
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Okamoto, Toshio |
| 著者 ローマ字 |
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en |
| 書誌情報 |
Biochemical and Biophysical Research Communications
巻 383,
号 4,
p. 475-479,
発行日 2009-06-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0006-291X |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.bbrc.2009.04.038 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.ncbi.nlm.nih.gov/pubmed?term=Transforming%20growth%20factor-%CE%B21%20induces%20matrix%20metalloproteinase-9%20expression%20in%20human%20meningeal%20cells%20via%20ERK%20and%20Smad%20pathways | http://www.ncbi.nlm.nih.gov/pubmed?term=Transforming%20growth%20factor-%CE%B21%20induces%20matrix%20metalloproteinase-9%20expression%20in%20human%20meningeal%20cells%20via%20ERK%20and%20Smad%20pathways |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Transforming growth factor (TGF)-β1, a cytokine released into the cerebrospinal fluid (CSF) after intraventricular hemorrhage (IVH), stimulates the expression of the components of the extracellular matrix (ECM), which causes progressive ventricular dilatation by impaired CSF absorption. Matrix metalloproteinase-9 (MMP-9), a proteinase involved in the removal of ECM proteins, has been shown to contribute to the resolution of progressive ventricular dilation after IVH. The aim of this study is to clarify the mechanism by which MMP-9 is expressed following IVH. Cultured human meningeal cells were treated with human recombinant TGF-β1. RT-PCR demonstrated that TGF-β1 induced MMP-9 expression in the meningeal cells in a dose-dependent manner. The TGF-β1-induced MMP-9 expression was attenuated in the presence of either MEK or Smad 3 inhibitor. Our data indicated that MMP-9 is released into the CSF from meningeal cells in response to TGF-β1, most probably through the activation of ERK and Smad pathways. |
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言語 |
en |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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19371720 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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979 |
2827.pdf (1.9 MB)
