| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2010-02-01 |
| タイトル |
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タイトル |
Differential changes in axonal conduction following CNS demyelination in two mouse models |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| その他（別言語等）のタイトル |
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その他のタイトル |
Differential changes in axonal conduction following central nervous system demyelination in two mouse models |
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言語 |
en |
| 著者 |
吉田, 成孝
Bando, Y
Takakusaki, K
Ito, S
Terayama, R
Kashiwayanagi, M
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| 著者 ローマ字 |
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Yoshida, Shigetaka |
| 著者 ローマ字 |
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en |
| 書誌情報 |
European Journal of Neuroscience
巻 28,
号 9,
p. 1731-1742,
発行日 2008-11-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0953-816X |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1111/j.1460-9568.2008.06474.x |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://dx.doi.org/10.1111/j.1460-9568.2008.06474.x | http://dx.doi.org/10.1111/j.1460-9568.2008.06474.x |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Transgenic and disease model mice have been used to investigate the molecular mechanisms of demyelinating diseases. However, less attention has been given to elucidating changes in nerve conduction in these mice. We established an experimental system to measure the response latency of cortical neurons and examined changes in nerve conduction in cuprizone-induced demyelinating mice and in myelin basic protein-deficient shiverer mice. Stimulating and recording electrodes were placed in the right and left sensori-motor cortices respectively. Electrical stimulation of the right cortex evoked antidromic responses in left cortical neurons with a latency of 9.38 ± 0.31 ms (N=107; mean ± SEM). While response latency was longer in mice at 7 days and 4 weeks of cuprizone treatment (12.35 ± 0.35 ms; N=102, 11.72 ± 0.29 ms; N=103, respectively), response latency at 7 days and 4 weeks after removal of cuprizone was partially restored (10.72 ± 0.45 ms; N=106 and 10.27 ± 0.34 ms; N=107, respectively). Likewise, electron microscopy showed cuprizone-induced demyelination in the corpus callosum and nearly complete remyelination after cuprizone removal. We also examined whether the myelin abnormalities in shiverer mice affected their response latencies. But there were no significant differences in response latencies in shiverer (9.83 ± 0.24 ms; N=103) and wild type (9.33 ± 0.22 ms; N=112) mice. The results of these electrophysiological assessments imply that different demyelinating mechanisms, differentially affecting axon conduction, are present in the cuprizone-treated and shiverer mice, and may provide new insights to understanding the pathophysiology of demyelinatation in animal models in the CNS. |
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言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
The definitive version is available at www.blackwell-synergy.com |
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言語 |
en |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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18973589 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1358 |
2821.pdf (810.2 kB)
