| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2010-02-01 |
| タイトル |
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|
タイトル |
Effects of Bone Marrow and Hepatocyte Transplantation on Liver Injury |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
稲垣, 光裕
Zhang, B
Jiang, B
Miyakoshi, M
Arikura, J
Ogawa, K
Kasai, S
|
| 著者 ローマ字 |
|
|
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Inagaki, Mitsuhiro |
| 著者 ローマ字 |
|
|
|
en |
| 書誌情報 |
Journal of Surgical Research
巻 157,
号 1,
p. 71-80,
発行日 2009-11-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0022-4804 |
| DOI |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1016/j.jss.2008.12.013 |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://www.ncbi.nlm.nih.gov/pubmed/19345373 | http://www.ncbi.nlm.nih.gov/pubmed/19345373 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: The therapeutic effects of bone marrow and hepatocyte transplantation were investigated regarding the treatment of retrorsine-partial hepatectomy-induced liver injury. Methods: Analbuminemic F344alb rats were given two doses of retrorsine 2 wk apart, followed 4 wk later by transplantation with F344 rat bone marrow cells or hepatocytes immediately after a two-thirds hepatectomy. The survival rate, liver regeneration rate, liver functions, albumin-positive hepatocytes, and normal albumin gene sequences in the liver and serum albumin levels were investigated in the recipients. Results: Although 65% retrorsine/partial hepatectomy-treated F344alb died between 1 and 11 d after the partial hepatectomy, only 27.5% of the animals died following bone marrow transplantation, and 50% with hepatocyte transplantation. Both bone marrow and hepatocyte transplantation ameliorated acute liver injury after a partial hepatectomy. Bone marrow transplantation yielded a very small increase in the number of albumin-positive hepatocytes in the liver, while hepatocyte transplantation resulted in massive replacement of the liver tissues by the donor hepatocytes associated with an elevation of serum albumin after an extended time. Conclusions: Both bone marrow and hepatocyte transplantation could prevent acute hepatic injury, conceivably due to a paracrine mechanism. |
|
言語 |
en |
| 資源タイプ |
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内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
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19345373 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
839 |
2819.pdf (1.1 MB)
