| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2010-02-01 |
| タイトル |
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タイトル |
Inflammation as a cardiovascular risk factor and pulse wave velocity as a marker of early-stage atherosclerosis in the Japanese population. |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
西條, 泰明
Utsugi, M
Yoshioka, E
Fukui, T
Sata, F
Nakagawa, N
Hasebe, N
Yoshida, T
Kishi, R
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| 著者 ローマ字 |
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Saijo, Yasuaki |
| 著者 ローマ字 |
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en |
| 書誌情報 |
Environmental Health and Preventive Medicine
巻 14,
号 3,
p. 159-164,
発行日 2009-05-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1342-078X |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1007/s12199-009-0080-2 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://dx.doi.org/10.1007/s12199-009-0080-2 | http://dx.doi.org/10.1007/s12199-009-0080-2 |
| 抄録 |
|
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内容記述タイプ |
Abstract |
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内容記述 |
Inflammation and pulse wave velocity (PWV) are a potential risk factor and marker, respectively, for atherosclerosis in the primary prevention setting. Atherosclerosis is now generally accepted to be an inflammatory disorder of the arterial wall, and the high-sensitivity C-reactive protein (hs-CRP) level has been reported to be a strong predictor of cardiovascular events. High-sensitivity-CRP is associated with two factors related to inflammation: (1) the local production of CRP by atheromatous tissue or coronary artery smooth muscle cells and (2) adipose tissue as a potent source of inflammatory cytokines. Based on studies in North America and Europe, hs-CRP has been established as a cardiovascular risk factor and a cut-off value has been recommended. However, Japanese have lower hs-CRP values than their Western counterparts, partly because Japanese have a lower body mass index (BMI), which correlates positively to hs-CRP, and partly because lifestyle and genetic factors can affect hs-CRP values. Therefore, a cut-off value needs to be established by cohort studies for the Japanese population. Carotid-femoral PWV is most commonly measured by applanation tonometry, particularly in Europe, but this method is critically dependent upon the accurate placing of transducers over the arteries and is both time-consuming and complex. A novel device has been recently developed in Japan that measures brachial-ankle PWV (baPWV) using a volume-rendering method. Brachian-ankle PWV is a suitable screening method because of its technical simplicity and shorter measurement time. It is associated not only with conventional cardiovascular risk factors but also with new risk factors, such as inflammation, γ-glutamyltransferase, chronic kidney disease, and psychosocial factors. However, a suitable cut-off value has yet to be established. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
The original publication is available at springerlink.com |
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言語 |
en |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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19568843 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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939 |
2818.pdf (345.7 kB)
