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Mitogen-activated protein kinase inhibition augments the T cell response against HOXB7-expressing tumor through human leukocyte antigen upregulation

https://asahikawa-med.repo.nii.ac.jp/records/2000533
https://asahikawa-med.repo.nii.ac.jp/records/2000533
44e42dc4-031c-49d4-a5bb-ef683944dafd
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36285482.pdf 36285482.pdf (3 MB)
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Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2025-06-20
タイトル
タイトル Mitogen-activated protein kinase inhibition augments the T cell response against HOXB7-expressing tumor through human leukocyte antigen upregulation
言語 en
言語
言語 eng
キーワード
主題Scheme Other
キーワード HLA
キーワード
主題Scheme Other
キーワード HOXB7
キーワード
主題Scheme Other
キーワード MAPK
キーワード
主題Scheme Other
キーワード cancer immunotherapy
キーワード
主題Scheme Other
キーワード peptide vaccine
資源タイプ
資源タイプ journal article
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 Hiroki, Komatsuda

× Hiroki, Komatsuda

en Hiroki, Komatsuda

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Risa, Wakisaka

× Risa, Wakisaka

en Risa, Wakisaka

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Michihisa, Kono

× Michihisa, Kono

en Michihisa, Kono

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Takumi, Kumai

× Takumi, Kumai

en Takumi, Kumai

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Ryusuke, Hayashi

× Ryusuke, Hayashi

en Ryusuke, Hayashi

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Hidekiyo, Yamaki

× Hidekiyo, Yamaki

en Hidekiyo, Yamaki

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Ryosuke, Sato

× Ryosuke, Sato

en Ryosuke, Sato

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Toshihiro, Nagato

× Toshihiro, Nagato

en Toshihiro, Nagato

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Takayuki, Ohkuri

× Takayuki, Ohkuri

en Takayuki, Ohkuri

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Akemi, Kosaka

× Akemi, Kosaka

en Akemi, Kosaka

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Kenzo, Ohara

× Kenzo, Ohara

en Kenzo, Ohara

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Miki, Takahara

× Miki, Takahara

en Miki, Takahara

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Akihiro, Katada

× Akihiro, Katada

en Akihiro, Katada

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Hiroya, Kobayashi

× Hiroya, Kobayashi

en Hiroya, Kobayashi

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bibliographic_information en : Cancer science

巻 114, 号 2, p. 399-409, 発行日 2023-02-01
ISSN
収録物識別子タイプ PISSN
収録物識別子 1347-9032
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/cas.15619
リンクURL
内容記述タイプ Other
内容記述 https://onlinelibrary.wiley.com/doi/10.1111/cas.15619
言語 en
item_1716186501932
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 36285482
item_5_description_33
内容記述タイプ Abstract
内容記述 Homeobox B7 (HOXB7) is a master regulatory gene that regulates cell proliferation and activates oncogenic pathways. Overexpression of HOXB7 correlates with aggressive behavior and poor prognosis in patients with cancer. However, the expression and role of HOXB7 in head and neck squamous cell carcinoma (HNSCC) remain unclear. In this study, we observed that most samples from patients with oropharyngeal cancer and HNSCC expressed HOXB7. As no direct inhibitor has been reported, we identified a potent peptide epitope to target HOXB7-expressing tumors through immune cells. A novel HOXB7-derived peptide epitope (HOXB78-25 ) elicited antigen-specific and tumor-reactive promiscuous CD4+ T cell responses. These CD4+ T cells produced γ-interferon (IFN-γ) and had the direct ability to kill tumors through granzyme B. Notably, downregulation of HOXB7 using siRNA enhanced human leukocyte antigen class II expression on tumor cells by decreasing the phosphorylation of MAPK. Mitogen-activated protein kinase inhibition augmented IFN-γ production by HOXB7-reactive CD4+ T cell responses without decreasing the expression of HOXB7. These results suggest that combining HOXB7 peptide-based vaccine with MAPK inhibitors could be an effective immunological strategy for cancer treatment.
言語 en
注記
内容記述タイプ Other
注記 This is an open access article under the terms of the Creative Commons Attribution-NonCommercial
License, which permits use, distribution and reproduction
in any medium, provided the original work is properly cited and is not used for commercial purposes.
言語 en
出版タイプ
出版タイプ VoR
item_5_textarea_42
en
© 2022 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
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Cite as

Hiroki, Komatsuda, Risa, Wakisaka, Michihisa, Kono, Takumi, Kumai, Ryusuke, Hayashi, Hidekiyo, Yamaki, Ryosuke, Sato, Toshihiro, Nagato, Takayuki, Ohkuri, Akemi, Kosaka, Kenzo, Ohara, Miki, Takahara, Akihiro, Katada, Hiroya, Kobayashi, n.d., Mitogen-activated protein kinase inhibition augments the T cell response against HOXB7-expressing tumor through human leukocyte antigen upregulation: 399–409 p.

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