| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2025-06-17 |
| タイトル |
|
|
タイトル |
Correlation Among Body Composition Parameters and Long-Term Outcomes in Crohn's Disease After Anti-TNF Therapy |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
Crohn's disease |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
anti-TNF antibody |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
body composition |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
mesenteric fat index |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
skeletal muscle |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
visceral fat |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Katsuyoshi, Ando
Kyoko, Uehara
Yuya, Sugiyama
Yu, Kobayashi
Yuki, Murakami
Hiroki, Sato
Takehito, Kunogi
Takahiro, Sasaki
Keitaro, Takahashi
Nobuhiro, Ueno
Shin, Kashima
Kentaro, Moriichi
Hiroki, Tanabe
Toshikatsu, Okumura
Mikihiro, Fujiya
|
| bibliographic_information |
en : Frontiers in nutrition
巻 9,
p. 765209,
発行日 2022-04-01
|
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2296-861X |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3389/fnut.2022.765209 |
| リンクURL |
|
|
内容記述タイプ |
Other |
|
内容記述 |
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.765209/full |
|
言語 |
en |
| item_1716186501932 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
35433773 |
| item_5_description_33 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: The impact of the body composition on the pathophysiology and clinical course of Crohn's disease (CD) has not been fully elucidated.
Aims: To reveal the correlations among body composition and long-term outcomes in CD after anti-TNF therapy.
Methods: Ninety-one patients who received anti-TNF therapy as their first biologic treatment were enrolled. The skeletal muscle index (SMI), visceral and subcutaneous fat area (VFA, SFA), and the ratio of the VFA to SFA (mesenteric fat index; MFI) at the 3rd lumbar level were measured using computed tomography (CT) imaging before the induction. The correlation among the body composition and outcomes were retrospectively analyzed.
Results: The 5-year cumulative secondary failure- and resection-free rates in patients with a low SMI (39.1% and 64.8%) were significantly lower than those with a high SMI (67.5% and 92.7%; p = 0.0071 and 0.0022, respectively). The 5-year cumulative secondary failure-free rate in the patients with low VF (45.0%) was significantly lower than that in those with high VF (77.6%; p = 0.016), and the 5-year cumulative resection-free rate in patients with a high MFI (68.9%) was significantly lower than that in those with a low MFI (83.0%; p = 0.031). Additionally, patients with low age and BMI had significantly lower cumulative secondary failure- and resection-free rates than those with high age and BMI (low age: 37.4% and 71.2%; high age: 70.7% and 88.9%; p = 0.0083 and 0.027, respectively) (low BMI: 27.2% and 64.8%; high BMI: 68.3% and 87.9%; p = 0.014 and 0.030, respectively), respectively. In the multivariate analyses, a low SMI was the only independent risk factor for secondary failure (hazard ratio [HR] 2.15, 95% confidence interval [CI] 1.04-4.44), while low age (HR 4.06, 95% CI 1.07-15.4), a low SMI (HR 4.19, 95% CI 1.01-17.3) and high MFI were risk factors for bowel resection (HR 4.31, 95% CI 1.36-13.7).
Conclusion: The skeletal muscle mass and ratio of visceral to subcutaneous fat were suggested to reflect the long-term clinical outcome and may be helpful as prognostic markers after anti-TNF therapy in CD. |
|
言語 |
en |
| 注記 |
|
|
内容記述タイプ |
Abstract |
|
注記 |
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
| item_5_textarea_42 |
|
|
|
en |
|
|
© 2022 Ando, Uehara, Sugiyama, Kobayashi, Murakami, Sato, Kunogi, Sasaki, Takahashi, Ueno, Kashima, Moriichi, Tanabe, Okumura and Fujiya. |
35433773.pdf (1.3 MB)
.png)
