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Comparison of Placental HSD17B1 Expression and Its Regulation in Various Mammalian species
https://asahikawa-med.repo.nii.ac.jp/records/2000335
https://asahikawa-med.repo.nii.ac.jp/records/20003350ae8b3c3-4c99-43d4-abf0-a11e9e41189f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
K600 IslamMohammadSayful_TD.pdf (1.2 MB)
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| Item type | 学位論文 / Thesis or Dissertation_02(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-02-17 | |||||||
| タイトル | ||||||||
| タイトル | Comparison of Placental HSD17B1 Expression and Its Regulation in Various Mammalian species | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | HSD17B1 | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | androstenedione | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | human | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | ovine | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | placenta | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | testosterone | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| その他（別言語等）のタイトル | ||||||||
| その他のタイトル | 多様な哺乳類における胎盤HSD17B1遺伝子の発現とその制御の比較 | |||||||
| 言語 | ja | |||||||
| 著者 |
Islam, Mohammad Sayful
× Islam, Mohammad Sayful
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| bibliographic_information |
en : Animals : an open access journal from MDPI 巻 13, 号 4, p. 622, 発行日 2023-02-10 |
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| ISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 2076-2615 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.3390/ani13040622 | |||||||
| 識別番号 その他 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | PMID:36830409 | |||||||
| 言語 | en | |||||||
| dissertation_number | ||||||||
| 学位授与番号 | 甲第600号 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2024-03-25 | |||||||
| 学位名 | ||||||||
| 言語 | ja | |||||||
| 学位名 | 博士（医学） | |||||||
| item_10_degree_grantor_32 | ||||||||
| 言語 | ja | |||||||
| 学位授与機関名 | 旭川医科大学 | |||||||
| item_10_description_33 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | During mammalian gestation, large amounts of progesterone are produced by the placenta and circulate for the maintenance of pregnancy. In contrast, primary plasma estrogens are different between species. To account for this difference, we compared the expression of ovarian and placental steroidogenic genes in various mammalian species (mouse, guinea pig, porcine, ovine, bovine, and human). Consistent with the ability to synthesize progesterone, CYP11A1/Cyp11a1, and bi-functional HSD3B/Hsd3b genes were expressed in all species. CYP17A1/Cyp17a1 was expressed in the placenta of all species, excluding humans. CYP19A/Cyp19a1 was expressed in all placental estrogen-producing species, whereas estradiol-producing HSD17B1 was only strongly expressed in the human placenta. The promoter region of HSD17B1 in various species possesses a well-conserved SP1 site that was activated in human placental cell line JEG-3 cells. However, DNA methylation analyses in the ovine placenta showed that the SP1-site in the promoter region of HSD17B1 was completely methylated. These results indicate that epigenetic regulation of HSD17B1 expression is important for species-specific placental sex steroid production. Because human HSD17B1 showed strong activity for the conversion of androstenedione into testosterone, similar to HSD17B1/Hsd17b1 in other species, we also discuss the biological significance of human placental HSD17B1 based on the symptoms of aromatase-deficient patients. | |||||||
| 言語 | en | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
