A natural Nrf2 activator glucoraphamin improves hepatic steatosis in high-fat diet-induced obese male mice associated with AMPK activation

Promsuwan, Suratsawadee

doi:https://doi.org/10.1007/s13340-023-00658-6

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A natural Nrf2 activator glucoraphamin improves hepatic steatosis in high-fat diet-induced obese male mice associated with AMPK activation

https://asahikawa-med.repo.nii.ac.jp/records/2000333

名前 / ファイル	ライセンス	アクション
K598 Promsuwan Suratsawadee_TD.pdf (2.1 MB)

Item type

学位論文 / Thesis or Dissertation_02(1)

公開日

2025-02-17

タイトル

A natural Nrf2 activator glucoraphamin improves hepatic steatosis in high-fat diet-induced obese male mice associated with AMPK activation

言語

eng

キーワード

言語

主題Scheme

Other

主題

AMP kinase

キーワード

言語

主題Scheme

Other

主題

Glucoraphanin

キーワード

言語

主題Scheme

Other

主題

Inflammation

キーワード

言語

主題Scheme

Other

主題

Macrophage polarization

キーワード

言語

主題Scheme

Other

主題

NAFLD

資源タイプ

資源タイプ識別子

http://purl.org/coar/resource_type/c_db06

資源タイプ

doctoral thesis

アクセス権

open access

アクセス権URI

http://purl.org/coar/access_right/c_abf2

その他（別言語等）のタイトル

その他のタイトル

天然Nrf2活性化因子グルコラファニンは、AMPK活性化を介して高脂肪食誘発性肥満雄マウスにおける脂肪肝を改善する

言語

著者

Promsuwan, Suratsawadee

bibliographic_information

en : Diabetology international

巻 15, 号 1, p. 86-98, 発行日 2023-08-29

ISSN

収録物識別子タイプ

PISSN

収録物識別子

2190-1678

DOI

識別番号その他

内容記述タイプ

Other

内容記述

PMID:38264234

言語

dissertation_number

学位授与番号

甲第598号

学位授与年月日

2023-12-25

学位名

言語

学位名

博士（医学）

item_10_degree_grantor_32

言語

学位授与機関名

旭川医科大学

item_10_description_33

内容記述タイプ

Abstract

内容記述

Genetic and pharmacological activation of the transcription factor nuclear factor, erythroid derived 2, like 2 (Nrf2) alleviates high-fat diet (HFD)-induced obesity in mice; however, synthetic Nrf2 activators are not clinically available due to safety concerns. Dietary glucoraphanin (GR), a naturally occurring compound found in cruciferous vegetables that activates Nrf2 and induces its target antioxidant genes. We previously demonstrated that GR increased thermogenesis and mitigated HFD-induced obesity in lean healthy mice. In this study, we investigated the therapeutic effects of GR on pre-existing obesity and associated metabolic disorders, such as hepatic steatosis, with or without low-fat dietary intervention. Eight-week-old male C57BL/6J mice were fed an HFD for 9 weeks to induce obesity. Subsequently, these obese mice were fed either the HFD or a normal chow diet, supplemented with or without GR, for an additional 11 weeks. GR supplementation did not decrease the body weight of HFD-fed mice; however, it significantly reduced plasma alanine aminotransferase and aspartate aminotransferase levels and hepatic triglyceride accumulation. These improvements in liver damage by GR were associated with decreased expression levels of fatty acid synthesis genes and proinflammatory chemokine genes, suppressed c-Jun N-terminal kinase activation, and reduced proinflammatory phenotypes of macrophages in the liver. Moreover, metabolome analysis identified increased hepatic levels of adenosine 5'-monophosphate (AMP) in HFD-GR mice compared with those in HFD mice, which agreed with increased phosphorylation levels of AMP-activated protein kinase. Our results show that GR may have a therapeutic potential for treating obesity-associated hepatic steatosis.

言語

出版タイプ

VoR

出版タイプResource

http://purl.org/coar/version/c_970fb48d4fbd8a85

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