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  1. Public
  2. 学位論文
  3. 博士論文2020.3~

Bacteria-derived ferrichrome inhibits tumor progression in sporadic colorectal neoplasms and colitis-associated cancer

https://asahikawa-med.repo.nii.ac.jp/records/2000280
https://asahikawa-med.repo.nii.ac.jp/records/2000280
1daa8701-7cf7-48fc-aab8-8b642a434d4e
名前 / ファイル ライセンス アクション
K561 K561 Iwama Takuya_TD.pdf (6.7 MB)
Item type 学位論文 / Thesis or Dissertation_02(1)
公開日 2025-01-21
タイトル
タイトル Bacteria-derived ferrichrome inhibits tumor progression in sporadic colorectal neoplasms and colitis-associated cancer
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 Colorectal cancer
キーワード
言語 en
主題Scheme Other
主題 DDIT3
キーワード
言語 en
主題Scheme Other
主題 Ferrichrome
キーワード
言語 en
主題Scheme Other
主題 Organoid
キーワード
言語 en
主題Scheme Other
主題 Probiotics
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
その他(別言語等)のタイトル
その他のタイトル 細菌由来のフェリクロームは散発性大腸腫瘍および大腸炎関連癌の腫瘍進行を抑制する
言語 ja
著者 岩間, 琢哉

× 岩間, 琢哉

ja 岩間, 琢哉

ja-Kana イワマ, タクヤ

en Iwama, Takuya

Search repository
bibliographic_information en : Cancer cell international

巻 21, 号 1, p. 21, 発行日 2020-01-01
ISSN
収録物識別子タイプ PISSN
収録物識別子 1475-2867
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/s12935-020-01723-9
識別番号 その他
内容記述タイプ Other
内容記述 PMID:33407519
言語 en
dissertation_number
学位授与番号 甲第561号
学位授与年月日
学位授与年月日 2021-06-30
学位名
言語 ja
学位名 博士(医学)
item_10_degree_grantor_32
言語 ja
学位授与機関名 旭川医科大学
item_10_description_33
内容記述タイプ Abstract
内容記述 Background: Colorectal cancers develop through several pathways, including the adenoma-carcinoma sequence and colitis-associated carcinogenesis. An altered intestinal microflora has been reported to be associated with the development and progression of colorectal cancer via these pathways. We identified Lactobacillus casei-derived ferrichrome as a mediator of the bacterial anti-tumor effect of colorectal cancer cells through the upregulation of DDIT3. In this study, we investigated the anti-tumor effects of ferrichrome on precancerous conditions and cancer cells associated with sporadic as well as colitis-associated colorectal cancer.

Methods: SRB and MTT assays were performed to assess growth inhibition in vitro. Eighteen organoids were prepared from biopsy specimens obtained by colonoscopy. An AOM-DSS carcinogenesis model and xenograft model of colorectal cancer cells were generated for the assessment of the tumor suppressive effect of ferrichrome in vivo.

Results: Ferrichrome inhibited the cell growth of colorectal cancer cells in vitro and in in vivo xenograft models. Ferrichrome exerted a strong tumor-suppressive effect that was superior to that of currently available anti-tumor agents, including 5-FU and cisplatin, both in vitro and in vivo. The tumor-suppressive effect of the combination of ferrichrome and 5-FU was superior to that of single treatment with either drug. The tumor suppressive effects of ferrichrome were confirmed through the upregulation of DDIT3 in patient-derived organoids of adenoma and carcinoma. Ferrichrome inhibited the tumor progression in the AOM-DSS model while exhibiting no anti-inflammatory effect in the DSS-colitis model, suggesting that ferrichrome inhibited cancer cells, but not a precancerous condition, via the colitis-associated pathway.

Conclusions: Ferrichrome exerts a tumor suppressive effect on precancerous conditions and cancer cells associated with sporadic as well as colitis-associated colorectal cancer. The anti-tumor effect of ferrichrome was mediated by the upregulation of DDIT3, and was superior to that of 5-FU or cisplatin. These results suggest that Lactobacillus brevis-derived ferrichrome may be a candidate anti-tumor drug for the treatment of colorectal neoplasms.
言語 en
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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