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Mammalian cerebral metabolism and amino acid neurotransmission during hibernation
https://asahikawa-med.repo.nii.ac.jp/records/1853
https://asahikawa-med.repo.nii.ac.jp/records/1853e7c1e2bc-4ea2-42ed-b4b7-826a0bd8276c
| 名前 / ファイル | ライセンス | アクション |
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2417.pdf (500.6 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||
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| 公開日 | 2009-09-09 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Mammalian cerebral metabolism and amino acid neurotransmission during hibernation | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
橋本, 眞明
× 橋本, 眞明
× Osborne, PG
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| 著者 ローマ字 | ||||||||||||
| Hashimoto, Masaaki | ||||||||||||
| 著者 ローマ字 | ||||||||||||
| en | ||||||||||||
| 書誌情報 |
Journal of Neurochemistry 巻 106, 号 4, p. 1888-1899, 発行日 2008-08-01 |
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| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0022-3042 | |||||||||||
| DOI | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.1111/j.1471-4159.2008.05543.x | |||||||||||
| リンクURL | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | http://dx.doi.org/10.1111/j.1471-4159.2008.05543.x | http://dx.doi.org/10.1111/j.1471-4159.2008.05543.x | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | This report demonstrates that during the torpor phase of hibernation, hamsters utilize ^<14>C and ^<13>C glucose in torpor specific brain metabolic pathways. Microdialysis of ^<14>C glucose into the striatum rapidly induced a steady state labelling of ECF lactate and labelling of tissue GABA, glutamate (GLU), glutamine (GLN) and alanine in ipsilateral and contralateral striata. The same tissue metabolites were labelled in cortex, hypothalamus and brainstem after microdialysis of ^<14>C lactate into the lateral ventricle. Serine, aspartate, glycine, taurine, tyrosine and methionine were not synthesised from glucose or lactate during torpor. ECF levels of amino and organic acids were low and unchanging during torpor and increased late during arousal to cenothermia. Labelled intracellular ^<14>C GABA and GLU were not communicated to the striatal ECF or ventricular space during torpor. ^<13>C NMR demonstrated rapid formation of lactate and functional TCA cycles in GABAergic and glutamatergic neurons, and enrichment of GLN and alanine after IV ^<13>C glucose. Large changes in tissue levels of amino acids occur prior to or during entrance into torpor but not during torpor. It is proposed that cerebral intracellular dehydration, the enlargement of ECF and the biochemistries associated with brain water homeostasis may have a role in regulating hibernation. | |||||||||||
| 言語 | en | |||||||||||
| 注記 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 注記 | The definitive version is available at www.blackwell-synergy.com author | |||||||||||
| 言語 | en | |||||||||||
| 資源タイプ | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 資源タイプ | text | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | AM | |||||||||||
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| 内容記述タイプ | Other | |||||||||||
| 内容記述 | application/pdf | |||||||||||
| ID(XooNIps) | ||||||||||||
| 18624914 | ||||||||||||
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| ダウンロード数(XooNIps) | ||||||||||||
| 883 | ||||||||||||
