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Identification of novel keratinocyte differentiation modulating compounds by high-throughput screening

https://asahikawa-med.repo.nii.ac.jp/records/1681
https://asahikawa-med.repo.nii.ac.jp/records/1681
829f8a2a-34fa-4b60-8e39-3fa6c751feaa
名前 / ファイル ライセンス アクション
2218.pdf 2218.pdf (3.0 MB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2009-06-16
タイトル
タイトル Identification of novel keratinocyte differentiation modulating compounds by high-throughput screening
言語 en
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 本間, 大

× 本間, 大

ja 本間, 大

ja-Kana ホンマ, マサル

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Stubbs, M

× Stubbs, M

en Stubbs, M

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Aherne, W

× Aherne, W

Aherne, W

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Workman, P

× Workman, P

en Workman, P

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Watt, FM

× Watt, FM

Watt, FM

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著者 ローマ字
Honma, Masaru
著者 ローマ字
en
書誌情報 Journal of biomolecular screening

巻 11, 号 8, p. 977-984, 発行日 2006-01-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 1087-0571
DOI
識別子タイプ DOI
関連識別子 10.1177/1087057106292556
リンクURL
内容記述タイプ Other
内容記述 http://www.ncbi.nlm.nih.gov/pubmed | http://www.ncbi.nlm.nih.gov/pubmed
抄録
内容記述タイプ Abstract
内容記述 We have attempted a high throughput-screening to find differentiation modifying compounds of keratinocyte. 11 inhibitors of known signaling pathway and approximately 4000 chemical compounds were screened using an In Cell Western system based on immunofluorescent staining. Staurosporine, a protein kinase C inhibitor and H89, a protein kinase A inhibitor, promote the expression of involucrin, a terminal differentiation marker in keratinocytes. On the other hand, U0126, a MEK1 specific inhibitor, and SAHA or SBHA, two HDAC inhibitors, prevent the expression of involucrin during calcium induced differentiation. In addition, we have found a novel compound that induces differentiation and two compounds that inhibit the differentiation of keratinocytes. One of these compounds also induced differentiation of a SCC cell line as well as apoptosis with a lower IC50 than that towards primary keratinocyte. These compounds might be useful in the future as tools to study differentiation of stratified epithelium as well as putative anti-tumor targets.
言語 en
注記
内容記述タイプ Other
注記 ‘The final, definitive version of this paper has been published in Journal of biomolecular screening, 11/8, Dec/2006 SAGE Publications Ltd., All rights reserved, 2006 by SAGE Publications Ltd at the Journal of biomolecular screening page: http://jbx.sagepub.com/ on SAGE Journals Online: http://online.sagepub.com/
\nauthor
言語 en
資源タイプ
内容記述タイプ Other
資源タイプ text
フォーマット
内容記述タイプ Other
内容記述 application/pdf
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17092913
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