| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2009-04-24 |
| タイトル |
|
|
タイトル |
Effect of ursodeoxycholic acid and chenodeoxycholic acid on major histocompatibility complex class I gene expression. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
平野, 史倫
Tanaka, H
Makino, Y
Okamoto, K
Makino, I
|
| 著者 ローマ字 |
|
|
|
Hirano, Fuminori |
| 著者 ローマ字 |
|
|
|
en |
| 書誌情報 |
Journal of Gastroenterology
巻 31,
号 1,
p. 55-60,
発行日 1996-01-01
|
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0944-1174 |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/BF01211187 |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://dx.doi.org/10.1007/BF01211187 | http://dx.doi.org/10.1007/BF01211187 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
We investigated effect of ursodeoxycholic acid on major histocompatibility complex class I gene expression in cultured human hepatoma cells. Ursodeoxycholic acid, which has recently been used for treatment of various autoimmune liver diseases, paradoxically increased mRNA level of major histocompatibility complex class I. However, endogenous bile acids, for example, chenodeoxycholic acid, more strongly increased major histocompatibility complex class I mRNA expression when compared with ursodeoxycholic acid. Concerning interplay between ursodeoxycholic acid and chenodeoxycholic acid, these bile acids additively induced major histocompatibility complex class I mRNA expression. In contrast, when total concentration of ursodeoxycholic acid and chenodeoxycholic acid was kept constant, expression of major histocompatibility complex class I mRNA appeared to be rather decreased in a dose-dependent manner along with increasing ratio of ursodeoxycholic acid. These data might indicate that the beneficial action of ursodeoxycholic acid is related to this relative decrease in major histocompatibility complex class I gene expression. |
|
言語 |
en |
| 注記 |
|
|
内容記述タイプ |
Other |
|
注記 |
The original publication is available at springerlink.com |
|
言語 |
en |
| 資源タイプ |
|
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内容記述タイプ |
Other |
|
資源タイプ |
text |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
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|
8808429 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
772 |
2028.pdf (107.1 kB)
