ログイン
言語:

WEKO3

  • トップ
  • ランキング
To

Field does not validate

To

Field does not validate

To
lat lon distance


インデックスリンク

インデックスツリー

  • RootNode

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. Public
  1. Public
  2. 国外雑誌論文

Focal cortical dysplasia: pathophysiological approach

https://asahikawa-med.repo.nii.ac.jp/records/136
https://asahikawa-med.repo.nii.ac.jp/records/136
9057a477-fc64-4ac5-a5a3-fc7ce07e8db1
名前 / ファイル ライセンス アクション
215.pdf 215.pdf (485.3 kB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2007-02-14
タイトル
タイトル Focal cortical dysplasia: pathophysiological approach
言語 en
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 程塚, 明

× 程塚, 明

程塚, 明

ja-Kana ホドヅカ, アキラ

Search repository
Tsuda, H

× Tsuda, H

Tsuda, H

Search repository
Hashizume, K

× Hashizume, K

Hashizume, K

Search repository
Tanaka, T

× Tanaka, T

Tanaka, T

Search repository
著者 ローマ字
Hodozuka, Akira
書誌情報 CHILDS NERVOUS SYSTEM

巻 22, 号 8, p. 827-833, 発行日 2006-08-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 0256-7040
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1007/s00381-006-0136-1
リンクURL
内容記述タイプ Other
内容記述 http://www.springerlink.com/content/g6n2t787mln47p73/?p=e31520dd8d5a401ca267498d9c802428&pi=8 | http://www.springerlink.com/content/g6n2t787mln47p73/?p=e31520dd8d5a401ca267498d9c802428&pi=8
抄録
内容記述タイプ Abstract
内容記述 Overview: Clinical and experimental studies on focal cortical dysplasia (FCD) were carried out. Materials and methods: For the experimental study, an experimental FCD model of rats was developed. Twenty Wistar rats at 0–2 days after birth were used for the study. Kainic acid (KA) solution was injected stereotaxically into medial and lateral sites of the sensori-motor cortex. Bipolar electrodes were inserted in five rats. Their behavior and electroencephalogram (EEG) were recorded using a digital-video-EEG monitoring system. After observation periods of 1, 2, and 6 months, rats were perfused for pathological study. FCD was observed adjacent to the site of KA injection in all rats more than 1 month after the injection. Results and discussions: EEG recording demonstrated focal spike discharges in and around the site of injection. However, clinical seizure was not observed. Pathological studies showed decrease in GABA-A receptors and increase in GABA-B receptors not only in the lesion but also in perilesional areas. Fifteen surgical cases of FCD with intractable epilepsy were subjected to the clinical study. Neuro-imaging studies including high-resolution magnetic resonance imaging and single-photon emission computed tomography were performed. Conventional EEG studies demonstrated focal EEG abnormalities with epileptic phenomena. At surgery, intraoperative electrocorticography (ECoG) was performed to localize epileptic foci under neuroleptoanalgesia. Thirteen patients showed epileptiform discharges on preresection ECoG. All foci in non-eloquent areas were resected. Pathological studies including immunohistochemical staining were performed, and the characteristics of the FCD in relation to EEG findings were analyzed. Patients in whom total lesionectomy with complete focus resection was performed had favorable postoperative courses. Nine patients (64.3%) have been seizure-free with reduced medication, and significant improvement was achieved in two patients (14.3%). Electrophysiological examination revealed epileptogenecity not only in the lesions but also in perilesional areas. The immunohistochemical studies showed a decrease in GABA-A receptors and an increase in GABA-B receptors in both the lesions and perilesional areas, but N-methyl-d-aspartate receptors were almost negative in both areas. Glutamate R1 was decreased in both areas, but glutamate R2 was increased in both areas. These findings support the results of a electrophysiological study. Conclusions: In conclusion, not only the epileptic property of experimental focal cortical dysplasia but also perilesional epileptogenesis was demonstrated. These findings supported the results of surgery for patients with focal cortical dysplasia. In cases of FCD, total removal of the lesion and resection of the perilesional epileptic focus are needed for a good outcome.
注記
内容記述タイプ Other
注記 The original publication is available at www.springerlink.com.
\nauthor
資源タイプ
内容記述タイプ Other
資源タイプ text
著者版フラグ
出版タイプ AM
フォーマット
内容記述タイプ Other
内容記述 application/pdf
ID(XooNIps)
16763854
閲覧数(XooNIps)
ダウンロード数(XooNIps)
1042
戻る
0
views
See details
Views

Versions

Ver.1 2023-06-19 14:09:55.297598
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

程塚, 明, Tsuda, H, Hashizume, K, Tanaka, T, n.d., Focal cortical dysplasia: pathophysiological approach: 827–833 p.

Loading...

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3