| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2009-03-11 |
| タイトル |
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タイトル |
Intracisternal injection of orexin-A prevents ethanol-induced gastric mucosal damage in rats |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
奥村, 利勝
Yamada, H
Tanno, S
Takakusaki, K
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| 著者 ローマ字 |
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Okumura, Toshikatsu |
| 書誌情報 |
Journal of Gastroenterology
巻 42,
号 5,
p. 336-341,
発行日 2007-05-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0944-1174 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1007/s00535-007-2007-2 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://dx.doi.org/10.1007/s00535-007-2007-2 | http://dx.doi.org/10.1007/s00535-007-2007-2 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Accumulating evidence have indicated that orexin-A in the brain stimulates vagal flow projecting to the stomach. Since the vagal system palys an important role in gastric mucosal integrity, we examined in the present study the effect of central orexin-A on the development of gastric mucosal damage evoked by ethanol in rats. Intracisternal but not intraperitoneal injection of orexin-A significantly inhibited the severity of gastric mucosal damage by 70 % ethanol in a dose-dependent manner, suggesting that orexin-A acts in the brain to prevent ethanol-induced gastric mucosal damage. The anti-ulcer action was observed in rats received with central administration of orexin-A but not orexin-B, indicating that the action is mediated through orexin 1 receptors. The gastroprotective action of central orexin-A was blocked by pretreatment with atropine, N^w-nitro-L-arginine methylester or indomethacin, respectively All these results suggest that orexin-A acts in orexin 1 receptors in the brain to exert a gastroprotective action against ethanol. Vagal muscarinic system, nitric oxide and prostaglandins may mediate the cytoprotective action by central orexin-A. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
The original publication is available at springerlink.com
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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17530356 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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783 |
1615.pdf (285.0 kB)
