| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2009-03-11 |
| タイトル |
|
|
タイトル |
The Bacillus subtilis Quorum-Sensing Molecule CSF Contributes to Intestinal Homeostasis via OCTN2, a Host Cell Membrane Transporter |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| その他（別言語等）のタイトル |
|
|
その他のタイトル |
Quorum sensing CSF of B. subtilis, through OCTN2 transport, contributes to intestinal homeostasis |
| 著者 |
藤谷, 幹浩
Musch, MW
Nakagawa, Y
Hu, S
Alverdy, J
Kohgo, Y
Schneewind, O
Jabri, B
Chang, EB
|
| 著者 ローマ字 |
|
|
|
Fujiya, Mikihiro |
| 書誌情報 |
Cell Host & Microbe
巻 1,
号 4,
p. 299-308,
発行日 2007-06-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1931-3128 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.chom.2007.05.004 |
| リンクURL |
|
|
内容記述タイプ |
Other |
|
内容記述 |
http://dx.doi.org/10.1016/j.chom.2007.05.004 | http://dx.doi.org/10.1016/j.chom.2007.05.004 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Bacteria use quorum sensing molecules (QSMs) to communicate within as well as across species, however, the effects of QSM on eukaryotic host cells are less understood. We report that the quorum-sensing pentapeptide, competence and sporulation factor (CSF), of a Gram-positive bacterium Bacillus subtilis, activates key survival pathways including p38 MAP kinase and protein kinase B (Akt) in intestinal epithelial cells and also induces cytoprotective heat shock proteins (Hsps), the latter which prevent oxidant-induced intestinal epithelial cell injury and loss of barrier function. These effects of CSF depend on its uptake by an apical membrane organic cation transporter-2 (OCTN2). OCTN2-transported CSF therefore serves as an example of a unique mechanism of host-bacterial interactions allowing the host to monitor changes in colonic flora behavior or composition. |
| 注記 |
|
|
内容記述タイプ |
Other |
|
注記 |
author |
| 資源タイプ |
|
|
内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
|
|
出版タイプ |
AM |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
|
|
|
18005709 |
| 閲覧数(XooNIps) |
|
| ダウンロード数(XooNIps) |
|
|
|
4047 |
1610.pdf (968.7 kB)
