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Changes in urinary parameters after oral of potassium-sodium citrate and magnesium oxide to prevent urolithiasis

https://asahikawa-med.repo.nii.ac.jp/records/134
https://asahikawa-med.repo.nii.ac.jp/records/134
c27ce6c0-4463-439c-ac73-0c3f3e80bb89
名前 / ファイル ライセンス アクション
212.pdf 212.pdf (268.3 kB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2007-02-14
タイトル
タイトル Changes in urinary parameters after oral of potassium-sodium citrate and magnesium oxide to prevent urolithiasis
言語 en
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 加藤, 祐司

× 加藤, 祐司

加藤, 祐司

ja-Kana カトウ, ユウジ

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Yamaguchi, S

× Yamaguchi, S

Yamaguchi, S

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Yachiku, S

× Yachiku, S

Yachiku, S

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Nakazono, S

× Nakazono, S

Nakazono, S

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Hori, J

× Hori, J

Hori, J

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Wada, N

× Wada, N

Wada, N

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Hou, K

× Hou, K

Hou, K

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著者 ローマ字
Kato, Yuji
出版社 ローマ字
ELSEVIER SCIENCE INC
書誌情報 UROLOGY

巻 63, 号 1, p. 7-11, 発行日 2004-01-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 0090-4295
DOI
識別子タイプ DOI
関連識別子 10.1016/j.urology.2003.09.057
リンクURL
内容記述タイプ Other
内容記述 http://www.sciencedirect.com/science/journal/00904295 | http://www.sciencedirect.com/science/journal/00904295
抄録
内容記述タイプ Abstract
内容記述 Objectives: To examine urinary parameters among normal individuals and patients with calcium oxalate (CaOx) stones after oral administration of potassium-sodium citrate (Kna-Cit) and magnesium oxide (MgO). Urinary citrate and magnesium have been known as the inhibitors of CaOx stone formation. Supplementation with potassium-magnesium citrate prevents the recurrence of CaOx stones. Methods: Twenty-five male volunteers aged 21 to 42 years without a history of urinary stones were given either Kna-Cit or MgO, or both. Fourteen patients with recurrent CaOx stones were also given both supplements, and 24-hour urine samples were collected to determine the urinary parameters. Results: The administration of both Kna-Cit and MgO to the normal individuals increased the excretion of citrate, magnesium, and potassium by 70.0%, 44.2%, and 50.0%, respectively. These parameters increased less when Kna-Cit or MgO was administered individually. After administration of both supplements to the patients with stones, the citrate, magnesium, and potassium levels increased by 62.1%, 63.3%, and 25.3%, respectively, and oxalate decreased by 66.5%. In both normal individuals and patients, the ion activity product index of CaOx decreased significantly more after administration of the combination than with either compound alone or before administration. Conclusions: The combination of Kna-Cit and MgO is more effective than either supplement alone in inhibiting the crystallization of CaOx stones. The combination may improve the urinary parameters of patients with stones accompanied by hypocitraturia and/or hypomagnesuria.
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内容記述タイプ Other
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内容記述タイプ Other
資源タイプ text
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Cite as

加藤, 祐司, Yamaguchi, S, Yachiku, S, Nakazono, S, Hori, J, Wada, N, Hou, K, n.d., Changes in urinary parameters after oral of potassium-sodium citrate and magnesium oxide to prevent urolithiasis: 7–11 p.

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