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Chromosomal integrity of freeze-dried mouse spermatozoa after Cs-137 gamma-ray irradiation
https://asahikawa-med.repo.nii.ac.jp/records/132
https://asahikawa-med.repo.nii.ac.jp/records/1324f087c8b-ef2f-43fe-a44c-acecf699cbf8
| 名前 / ファイル | ライセンス | アクション |
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209.pdf (257.6 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||
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| 公開日 | 2007-02-14 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Chromosomal integrity of freeze-dried mouse spermatozoa after Cs-137 gamma-ray irradiation | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
日下部, 博一
× 日下部, 博一
× Kamiguchi, Y
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| 著者 ローマ字 | ||||||||||||
| Kusakabe, Hirokazu | ||||||||||||
| 出版社 ローマ字 | ||||||||||||
| ELSEVIER SCIENCE BV | ||||||||||||
| 書誌情報 |
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 巻 556, 号 1-2, p. 163-168, 発行日 2004-11-01 |
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| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0027-5107 | |||||||||||
| DOI | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.1016/j.mrfmmm.2004.08.001 | |||||||||||
| リンクURL | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | http://www.sciencedirect.com/science/journal/00275107 | http://www.sciencedirect.com/science/journal/00275107 | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | This study demonstrated that freeze-dried mouse spermatozoa possess strong resistance to ^137Cs γ-ray irradiation at doses of up to 8 Gy. Freeze-dried mouse spermatozoa were rehydrated and injected into mouse oocytes with an intracytoplasmic sperm injection (ICSI) technique. Most oocytes can be activated after ICSI by using spermatozoa irradiated with γ-rays before and after freeze-drying. Sperm chromosome complements were analyzed at the first cleavage metaphase. Chromosome aberrations increased in a dose-dependent manner in the spermatozoa irradiated before freeze-drying. However, no increase in oocytes with chromosome aberrations was observed when fertilized by spermatozoa that had been irradiated after freeze-drying, as compared with freeze-dried spermatozoa that had not been irradiated. These results suggest that both the chromosomal integrity of freeze-dried spermatozoa, as well as their ability to activate oocytes, were protected from γ-ray irradiation at doses at which chromosomal damage is found to be strongly induced in spermatozoa suspended in solution. | |||||||||||
| 注記 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 注記 | author | |||||||||||
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| 内容記述タイプ | Other | |||||||||||
| 資源タイプ | text | |||||||||||
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| 出版タイプ | AM | |||||||||||
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| 内容記述タイプ | Other | |||||||||||
| 内容記述 | application/pdf | |||||||||||
| ID(XooNIps) | ||||||||||||
| 15491644 | ||||||||||||
| 閲覧数(XooNIps) | ||||||||||||
| ダウンロード数(XooNIps) | ||||||||||||
| 2512 | ||||||||||||
