| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-02-14 |
| タイトル |
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|
タイトル |
Identification of human T-cell epitopes and highly immunogenic analog peptides on the non-typeable Haemophilus influenzae P6 outer membrane protein |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
石田, 芳也
Abe, Y
Yanai, M
Kobayashi, H
Harabuchi, Y
|
| 著者 ローマ字 |
|
|
|
Ishida, Yoshiya |
| 出版社 ローマ字 |
|
|
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ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 書誌情報 |
CLINICAL IMMUNOLOGY
巻 121,
号 1,
p. 90-99,
発行日 2006-10-01
|
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1521-6616 |
| DOI |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.clim.2006.06.005 |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://www.sciencedirect.com/science/journal/15216616 | http://www.sciencedirect.com/science/journal/15216616 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
P6 outer membrane protein is one of the candidates for a vaccine formulation against non-typeable Haemophilus influenzae (NTHi) infection. However, otitis-prone children who have recurrent episodes of acute otitis media due to NTHi fail to respond adequately to P6. An innovative approach to vaccination is therefore required to augment such children's immune response. To develop an effective peptide vaccine, we established P6-specific CD4^+ T-cell lines (TCLs) restricted by the human histocompatibility leukocyte antigen (HLA)-DR9 molecule, and revealed a human T-cell epitope on P6 and its core peptide sequence (p77–85; EYNIALGQR). Furthermore, we found that 3 analog peptides, E77D (the substitution of E at position 77 with D), N79G, and R85K, induced high proliferative responses as well as marked cytokine production when compared to the T-cell epitope peptide. These peptides may be candidates for a peptide vaccine formulation effective against NTHi infections, even in otitis-prone children. |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
author |
| 資源タイプ |
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内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
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|
16901757 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1225 |
204.pdf (588.3 kB)
