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NFAT2 IS AN ESSENTIAL MEDIATOR OF ORTHOPEDIC PARTICLE-INDUCED OSTEOCLASTOGENESIS

https://asahikawa-med.repo.nii.ac.jp/records/1170
https://asahikawa-med.repo.nii.ac.jp/records/1170
321f83b7-ce2f-48be-94fb-4b133a7a406b
名前 / ファイル ライセンス アクション
1409.pdf 1409.pdf (1.3 MB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2009-01-19
タイトル
タイトル NFAT2 IS AN ESSENTIAL MEDIATOR OF ORTHOPEDIC PARTICLE-INDUCED OSTEOCLASTOGENESIS
言語 en
言語
言語 eng
キーワード
主題Scheme Other
キーワード NFAT2、Osteoclast、PMMA、JNK
資源タイプ
資源タイプ journal article
著者 山中, 康裕

× 山中, 康裕

山中, 康裕

ja-Kana ヤマナカ, ヤスヒロ

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Abu-Amer, Wahid

× Abu-Amer, Wahid

Abu-Amer, Wahid

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Foglia, Domenica

× Foglia, Domenica

Foglia, Domenica

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Otero, Jesse

× Otero, Jesse

Otero, Jesse

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Clohisy, John

× Clohisy, John

Clohisy, John

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Abu-Amer, Yousef

× Abu-Amer, Yousef

Abu-Amer, Yousef

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著者 ローマ字
Yamanaka, Yasuhiro
書誌情報 Journal of Orthopedic Research

巻 26, 号 12, p. 1577-1584, 発行日 2008-12-01
DOI
識別子タイプ DOI
関連識別子 10.1002/jor.20714
リンクURL
内容記述タイプ Other
内容記述 http://www.ncbi.nlm.nih.gov/pubmed?term=NFAT2%20IS%20AN%20ESSENTIAL%20MEDIATOR%20OF%20ORTHOPEDIC%20PARTICLE-INDUCED%20OSTEOCLASTOGENESIS | http://www.ncbi.nlm.nih.gov/pubmed?term=NFAT2%20IS%20AN%20ESSENTIAL%20MEDIATOR%20OF%20ORTHOPEDIC%20PARTICLE-INDUCED%20OSTEOCLASTOGENESIS
抄録
内容記述タイプ Abstract
内容記述 Particle-induced periprosthetic osteolysis is the major cause for orthopedic implant failure. This failure is mediated mainly by the action of osteoclasts, the principal cells responsible for bone resorption and osteolysis. Therapeutic interventions to alleviate osteolysis have been focused on understanding and targeting mechanisms of osteoclastogenesis. The nuclear transcription factor NFAT is an essential terminal differentiation factor of osteoclastogenesis. This transcription factor is known to cooperate with c-jun/AP-1 in mediating RANKL-induced osteoclastogenesis. We have previously determined that RANKL is an essential cytokine mediator of particle-induced osteoclastogenesis, and that PMMA particles activate JNK and c-jun/AP-1 in bone marrow macrophages (osteoclast precursors). In the current study, we investigated the effect of PMMA particles on the NFAT signaling pathway in osteoclast precursor cells. Our findings point out that PMMA particles stimulate nuclear translocation of NFAT2 in wild-type osteoclast precursors, which is associated with increased osteoclastogenesis. More importantly, induction of osteoclastogenesis was selectively blocked in a dose-dependent fashion by the calcineurin inhibitors, Cyclosporine-A and FK506. Further, this activation was also blocked in a time-dependent fashion by the NFAT inhibitor VIVIT. Finally, we provide novel evidence that PMMA particles induce binding of NFAT2 and AP-1 proteins. Thus, our findings demonstrate that activation of the NFAT pathway in conjunction with MAP kinases is essential for basal and PMMA-stimulated osteoclastogenesis.
注記
内容記述タイプ Other
注記 Author
資源タイプ
内容記述タイプ Other
資源タイプ text
フォーマット
内容記述タイプ Other
内容記述 application/pdf
ID(XooNIps)
18655139
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ダウンロード数(XooNIps)
953
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Cite as

山中, 康裕, Abu-Amer, Wahid, Foglia, Domenica, Otero, Jesse, Clohisy, John, Abu-Amer, Yousef, n.d., NFAT2 IS AN ESSENTIAL MEDIATOR OF ORTHOPEDIC PARTICLE-INDUCED OSTEOCLASTOGENESIS: 1577–1584 p.

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