{"created":"2023-06-19T11:20:49.944080+00:00","id":915,"links":{},"metadata":{"_buckets":{"deposit":"e7a64990-e23e-4499-97fe-a2a47ea1b74f"},"_deposit":{"created_by":3,"id":"915","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"915"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000915","sets":["7","7:23"]},"author_link":["2725","2726","2727","2728","2729","2730","2731"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"218","bibliographicPageStart":"215","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"臨床薬理"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"健常者64名を対象に,wax-mediated host-start polymerase chain reaction(PCR)法がcytochrome P4502C9(CYP2C9)*1及び*3アレルを特異的に増殖させるかどうか検討した.連続的に希釈したDNAテンプレートをhost-start PCR法で増殖し,酵素分解なしにアガロースゲル電気泳動させたところ,10μgのDNAテンプレートでも非特異的増殖バンドなしにCYP2C9由来の165bpバンドがはっきり検出された.このバンドの濃さはテンプレート量に比例して増加した.一方waxを使用しないPCR法の場合,アレルの増殖は不規則であった.本法はCYP2C9*1及び*3アレル検出の感度を著明に増加させ,一貫した性能を持ち,バックグラウンドが低く,臨床的に有用であると考えられた","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0388-1601","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2003176923"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2216"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"696"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Suno, Manabu"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"須野, 学"},{"creatorName":"スノ, マナブ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2725","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Awaya, Toshio"}],"nameIdentifiers":[{"nameIdentifier":"2726","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Kento"}],"nameIdentifiers":[{"nameIdentifier":"2727","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohtaki, Ko-ichi"}],"nameIdentifiers":[{"nameIdentifier":"2728","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chiba, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"2729","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayase, Nobumasa"}],"nameIdentifiers":[{"nameIdentifier":"2730","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsubara, Kazuo"}],"nameIdentifiers":[{"nameIdentifier":"2731","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"1113.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"1113.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/915/files/1113.pdf"},"version_id":"c6381378-b991-49e0-8f6a-9bcf66139f1a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CYP2C9、genotyping、PCR、wax-mediated","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"the wax-mediated host-start polymerase chain reaction(PCR)法はCYP2C9*1及び*3アレルの遺伝子型同定を改善する(A Wax-Mediated Hot-Start Polymerase Chain Reaction Improves the Genotyping of CYP2C9* 1 and * 3 Alleles)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"the wax-mediated host-start polymerase chain reaction(PCR)法はCYP2C9*1及び*3アレルの遺伝子型同定を改善する(A Wax-Mediated Hot-Start Polymerase Chain Reaction Improves the Genotyping of CYP2C9* 1 and * 3 Alleles)","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","23"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-08-04"},"publish_date":"2008-08-04","publish_status":"0","recid":"915","relation_version_is_last":true,"title":["the wax-mediated host-start polymerase chain reaction(PCR)法はCYP2C9*1及び*3アレルの遺伝子型同定を改善する(A Wax-Mediated Hot-Start Polymerase Chain Reaction Improves the Genotyping of CYP2C9* 1 and * 3 Alleles)"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:50:00.628179+00:00"}