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Physician Scientistsに聞く 角化過程の理解と角化異常症,最近の到達点
https://asahikawa-med.repo.nii.ac.jp/records/886
https://asahikawa-med.repo.nii.ac.jp/records/886d60138e4-4f75-4792-b286-5543da3198d9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
1083.pdf (462.1 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2008-07-10 | |||||||||
| タイトル | ||||||||||
| タイトル | Physician Scientistsに聞く 角化過程の理解と角化異常症,最近の到達点 | |||||||||
| 言語 | ja | |||||||||
| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| キーワード | ichthyosis,keratin,lamellar granules,loricrin | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
山本, 明美
× 山本, 明美
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| 著者 ローマ字 | ||||||||||
| Yamamoto, Akemi | ||||||||||
| 書誌情報 |
日本皮膚科学会雑誌 巻 114, 号 13, p. 2048-2051, 発行日 2004-12-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0021-499X | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Recently there have been great advances in molecular understanding of two major keratinization disorders, loricrin keratoderma (LK) and ichthyosis hystrix, Curth-Macklin type (IHCM). In LK, the unique heterozygous mutations in the glycine-rich domain of the mutant loricrin form arginine-rich nuclear localization sequences that likely to disrupt differentiation of keratinocytes. In IHCM, a heterozygous frameshift mutation in the tail domain of K1 leads to specific cytoskeletal abnormalities in the differentiated keratinocytes. Present classification of keratinization disorders mainly based on clinical manifestations has to be modified based on recent findings in the molecular mechanisms. As to discoveries in basics of keratinization, we have recently proposed a new model of lemellar granules based on immunoelectron microscopic analysis. In this model, lemellar granules are parts of a branched tubular structure, where various lamellar granule cargoes are sequentially synthesized and independently transported from the trans-Golgi network. | |||||||||
| 注記 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 注記 | 著者版 | |||||||||
| 資源タイプ | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 資源タイプ | text | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
| ID(XooNIps) | ||||||||||
| 2005104897 | ||||||||||
| 閲覧数(XooNIps) | ||||||||||
| ダウンロード数(XooNIps) | ||||||||||
| 1453 | ||||||||||
