| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2008-06-30 |
| タイトル |
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タイトル |
Rab11 Is Associated with Epidermal Lamellar Granules |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
山本, 明美
Kishibe, M
Takahashi, H
Iizuka, H
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| 著者 ローマ字 |
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Yamamoto(Ishida), Akemi |
| 書誌情報 |
Journal of Investigative Dermatology
巻 127,
号 9,
p. 2166-2170,
発行日 2007-09-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0022-202X |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1038/sj.jid.5700850 |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://www.nature.com/jid/journal/v127/n9/full/5700850a.html | http://www.nature.com/jid/journal/v127/n9/full/5700850a.html |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Epidermal lamellar granules (LGs) are specialized organelles that transport and secrete various molecules, including lipids, proteases, protease inhibitors, and structural proteins, thereby providing a protective barrier against the environment. Abnormalities in LG-related molecules result in severe skin diseases, but their transport mechanisms are poorly understood. We studied the distribution of Rab11, a common GTPase in recycling endosomes, in normal human epidermis. Confocal laser scanning microscopy detected Rab11 immunoreactivity in differentiated epidermal keratinocytes. Staining was strong at the apical side of each cell, a pattern commonly seen in LG-associated molecules. Around the nuclei, Rab11 was colocalized with TGN46, a trans-Golgi network marker. Rab11 was also colocalized with known LG-molecules, namely lymphoepithelial Kazal-type-related inhibitor, corneodesmosine, cathepsin D, and glucosylceramides. Immunoelectron microscopy revealed that Rab11 was widely distributed along TGN and tubular-vesicular structures containing different LG molecules. The present results suggest that Rab11 plays a role in the intracellular trafficking of various types of LG-molecule from the TGN to the cell surface. |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
Nature Publishing Group, Journal of Investigative Dermatology, 127, 9, 2007, 2166-2170
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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17476295 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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883 |
1073.pdf (2.9 MB)
