WEKO3
アイテム
Brain ECF antioxidant interactions in hamsters during arousal from hibernation
https://asahikawa-med.repo.nii.ac.jp/records/876
https://asahikawa-med.repo.nii.ac.jp/records/8768b26da40-ddeb-4333-ad3d-af5617b8dc9a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
1072.pdf (421.5 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2008-06-30 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Brain ECF antioxidant interactions in hamsters during arousal from hibernation | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
Osborne, Peter G
× Osborne, Peter G
× Hashimoto, M
|
|||||||||||
| 書誌情報 |
Behavioural Brain Research 巻 178, 号 1, p. 115-122, 発行日 2007-03-01 |
|||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0166-4328 | |||||||||||
| DOI | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.1016/j.bbr.2006.12.006 | |||||||||||
| リンクURL | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | http://www.sciencedirect.com/science/journal/01664328 | http://www.sciencedirect.com/science/journal/01664328 | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Warming from hibernation to cenothermia involves intense metabolic activity and large fluxes in regional blood flow and volume. During this transition, levels of the antioxidants, ascorbate (AA), urate and glutathione (GSH) in brain tissue, extracellular fluid (ECF) and plasma change substantially. Striatal ECF was sampled and manipulated using very slow perfusion microdialysis to examine the mechanisms that influence the changing profile of striatal ECF AA, urate and GSH levels during arousal from hibernation to cenothermia in Syrian hamsters (Mesocricetus auratus). Omission of glucose from the perfusate had no effect upon the respective decrease, increase and transient increase in striatal ECF levels of AA, GSH and urate observed during arousal from hibernation to cenothermia. In contrast, inhibition of xanthine dehydrogenase/oxidase (XOR) activity by reverse dialysis with oxypurinol, itself a free radical scavenger, decreased ECF urate and preserved ECF AA levels. This suggests that some ECF AA is oxidized by free radical products of XOR flux and/or by other free radical producing processes activated during the transition from hibernation to cenothermia. Local supplementation of ECF AA, GSH and cystiene had no effect upon the profile of transient increase of ECF urate observed during arousal from hibernation. The production of free radicals by XOR and the disappearance of AA from the ECF continues for at least 2 h immediately after the hamster has attained cenothermia. The hamster, immediately after arousal from hibernation, can be utilized as a natural model to study free radical production and effective scavenging at cenothermia. | |||||||||||
| 注記 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 注記 | author | |||||||||||
| 資源タイプ | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 資源タイプ | text | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | AM | |||||||||||
| フォーマット | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | application/pdf | |||||||||||
| ID(XooNIps) | ||||||||||||
| 17207864 | ||||||||||||
| 閲覧数(XooNIps) | ||||||||||||
| ダウンロード数(XooNIps) | ||||||||||||
| 1178 | ||||||||||||
