| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2008-04-28 |
| タイトル |
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タイトル |
Decreased expression of retinoid X receptor isoforms in human thyroid carcinomas |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
滝山, 由美
Miyokawa, N
Sugawara, A
Kato, S
Ito, K
Sato, K
Oikawa, K
Kobayashi, H
Kimura, S
Tateno, H
|
| 著者 ローマ字 |
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Takiyama, Yumi |
| 書誌情報 |
Journal of Clinical Endocrinology & Metabolism
巻 89,
号 11,
p. 5851-5861,
発行日 2004-11-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0021-972X |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1210/jc.2003-032036 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://jcem.endojournals.org/ | http://jcem.endojournals.org/ |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Retinoid X receptors (RXRs) are ligand-inducible transcription factors that belong to the superfamily of nuclear hormone receptors. Because RXRs heterodimerize with thyroid hormone receptor, retinoic acid receptor, vitamin D(3) receptor, and peroxisome proliferator-activated receptor, they play central roles in regulating a number of signaling pathways. To understand the roles of RXRs in human thyroid carcinogenesis, we have investigated the immunohistochemical expression of RXRs in normal and neoplastic thyroid tissues. Whereas nontumorous human thyroid cells exhibited distinct nuclear staining for the RXRs, thyroid carcinomas showed decreased nuclear expression of all three RXR isoforms. In particular, some thyroid carcinoma cells showed intense RXR-alpha cytoplasmic staining accompanied by decreased immunoreactivity in their nuclei. This subcellular localization of RXR-alpha was confirmed by Western blot analysis, which showed both lower nuclear expression levels of RXR-alpha and a cytosolic presence of RXR-related protein in neoplastic regions. We present here, for the first time, the histological distribution of each RXR protein (alpha, beta, and gamma) in human thyroid follicular cells. In addition, we found that the nuclear expression of RXRs was lower in thyroid carcinomas than in normal tissue. The differential expressions of these RXRs in thyroid carcinomas might be implicated in the pathogenesis of thyroid cancers. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
Endocrine Society, Takiyama, Yumi ; Miyokawa, Naoyuki ; Sugawara, Akira ; Kato, Shizuo ; Ito, Koichi ; Sato, Keisuke ; Oikawa, Kensuke ; Kobayashi, Hiroya ; Kimura, Shoji ; Tateno, Masatoshi, Journal of Clinical Endocrinology & Metabolism, 89(11), 2004, 5851-5861.
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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15531552 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1637 |
979.pdf (1.1 MB)
