| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2008-03-28 |
| タイトル |
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タイトル |
Urodynamic effects of α1-blocker tamsulosin on voiding dysfunction in patients with neurogenic bladder |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
柿崎, 秀宏
Ameda, K
Kobayashi, S
Tanaka, H
Shibata, T
Koyanagi, T
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| 著者 ローマ字 |
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Kakizaki, Hidehiro |
| 書誌情報 |
International journal of urology
巻 10,
号 11,
p. 576-581,
発行日 2003-01-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0919-8172 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1046/j.1442-2042.2003.00710.x |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.blackwell-synergy.com/doi/abs/10.1046/j.1442-2042.2003.00710.x | http://www.blackwell-synergy.com/doi/abs/10.1046/j.1442-2042.2003.00710.x |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Backgroud: The therapeutic role of α-blockers in the treatment of voiding disorders due to benign prostatic hyperplasia has been extensively examined. To investigate a possible effect of α1-blocker on urodynamic voiding parameters in patients with neurogenic bladder, we conducted a clinical trial using tamsulosin. Methods: Twenty-four patients (14 men and 10 women) ranging from 24 to 82 years of age (mean age 61 years) with neurogenic bladder were analyzed. Urodynamic studies were performed before and after treatment with 0.4 mg tamsulosin daily for 4 weeks. Results: On uroflowmetry, the average flow rate (from 4.6 ± 3.3 to 6.7 ± 3.0 mL/s, P = 0.04), maximum flow rate (from 9.4 ± 6.8 to 14.1 ± 7.0 mL/s, P = 0.016) and residual urine rate (from 46 ± 29 to 32 ± 21%, P = 0.02) improved significantly. In patients with detrusor contraction during voiding, detrusor opening pressure and detrusor pressure at maximum flow decreased significantly from 69.0 ± 36.2 to 49.2 ± 26.4 cmH2O (P = 0.046) and from 66.7 ± 34.6 to 53.6 ± 26.5 cmH2O (P = 0.007), respectively. On the other hand, in patients with detrusor areflexia, vesical opening pressure (from 78.2 ± 23.4 to 61.6 ± 25.2 cmH2O), or vesical pressure at maximum flow (from 68.6 ± 23.2 to 62.9 ± 25.2 cmH2O) did not change significantly after treatment. Conclusion: Tamsulosin reduces functional urethral resistance during voiding and improves flow rate in patients with neurogenic bladder. It has more beneficial urodynamic effects in patients with detrusor contraction during voiding than in patients with detrusor areflexia. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
Blackwell Publishing, HIDEHIRO, KAKIZAKI ; KANAME, AMEDA ; SHINYA, KOBAYASHI ; HIROSHI, TANAKA ; TAKASHI, SHIBATA ; TOMOHIKO, KOYANAGI, International journal of urology, 10(11), 2003, 576-581. |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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14633081 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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745 |
898.pdf (260.0 kB)
