| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2008-03-28 |
| タイトル |
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タイトル |
Cathelicidin antimicrobial peptides are expressed in salivary glands and saliva |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
村上, 正基
Ohtake, T
Dorshner, RA
Gallo, RL
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| 著者 ローマ字 |
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Murakami, Masamoto |
| 書誌情報 |
Journal of dental research
巻 81,
号 12,
p. 845-850,
発行日 2002-01-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0022-0345 |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1177/154405910208101210 |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://www.ncbi.nlm.nih.gov/pubmed/12454100 | http://www.ncbi.nlm.nih.gov/pubmed/12454100 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The expression of antimicrobial peptides at epithelial surfaces such as skin, lung, and intestine is thought to provide protection against infection. Cathelicidin antimicrobial peptides are essential for the protection of skin against invasive bacterial infection. To determine if cathelicidins are also present in the oral cavity, we examined the expression of both mRNA and protein in mice and human saliva. The murine cathelicidin (CRAMP) was detected in the adult by reverse-transcription/polymerase chain-reaction (RT-PCR), and in embryonic, newborn, and adult tissues by in situ hybridization and immunohistochemistry. CRAMP mRNA and protein were localized to the salivary glands, specifically in acinar cells of the submandibular gland and palatine minor glands, as well as in lingual epithelium and palatal mucosa. In man, the human cathelicidin LL-37 was detected in human saliva by Western blotting. These results indicate that cathelicidins are present in the salivary system, in some oral epithelia, and in saliva, contributing to broad-spectrum defense of the oral cavity. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
International & American Associations for Dental Research, Murakami, M. ; Ohtake, T. ; Dorshner, RA. ; Gallo, RL., Journal of dental research, 81(12), 2002, 845-850.
\npublisher |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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12454100 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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2256 |
897.pdf (1.8 MB)
