{"created":"2023-06-19T11:20:38.882128+00:00","id":710,"links":{},"metadata":{"_buckets":{"deposit":"3a83b488-d885-4bf2-a95c-e03910384980"},"_deposit":{"created_by":3,"id":"710","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"710"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000710","sets":["7","7:24"]},"author_link":["1951","1952","1953","1954","1955"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"213","bibliographicPageStart":"205","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"Japanese Journal of Physiology"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.ncbi.nlm.nih.gov/pubmed?term=Repeated%20immobilization%20stress%20increases%20uncoupling%20protein%201%20expression%20and%20activity%20in%20Wistar%20rats | http://www.ncbi.nlm.nih.gov/pubmed?term=Repeated%20immobilization%20stress%20increases%20uncoupling%20protein%201%20expression%20and%20activity%20in%20Wistar%20rats","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Repeat immobilization-stressed rats are leaner and have improved cold tolerance due to enhancement of brown adipose tissue (BAT) thermogenesis. This process likely involves stress-induced sympathetic nervous system activation and adrenocortical hormone release, which dynamically enhances and suppresses uncoupling protein 1 (UCP1) function, respectively. To investigate whether repeated immobilization influences UCP1 thermogenic properties, we assessed UCP1 mRNA, protein expression, and activity (GDP binding) in BAT from immobilization-naïve or repeatedly immobilized rats (3 h daily for 4 weeks) and sham operated or adrenalectomized (ADX) rats. UCP1 properties were assessed before (basal) and after exposure to 3 h of acute immobilization. Basal levels of GDP binding and UCP1 expression was significantly increased (140 and 140%) in the repeated immobilized group. Acute immobilization increased GDP binding in both naïve (180%) and repeated immobilized groups (220%) without changing UCP1 expression. In ADX rats, basal GDP binding and UCP1 gene expression significantly increased (140 and 110%), and acute immobilization induced further increase. These data demonstrate that repeated immobilization resulted in enhanced UCP1 function, suggesting that enhanced BAT thermogenesis contributes to lower body weight gain through excess energy loss and an improved ability to maintain body temperature during cold exposure.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"The Physiological Society of Japan , Gao, Bihu ; Kikuchi-Utsumi, Kazue ; Ohinata, Hiroshi ; Hashimoto, Masaaki ; Kuroshima, Akihiro, Japanese Journal of Physiology, 53(3), 2003, 205-213.\n\\npublisher","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2170/jjphysiol.53.205","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-521X","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"14529581"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2368"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"3228"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Hashimoto, Masaaki"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"橋本, 眞明"},{"creatorName":"ハシモト, マサアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1951","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Gao, B"}],"nameIdentifiers":[{"nameIdentifier":"1952","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kikuchi-Utsumi, K"}],"nameIdentifiers":[{"nameIdentifier":"1953","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohinata, H"}],"nameIdentifiers":[{"nameIdentifier":"1954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuroshima, A"}],"nameIdentifiers":[{"nameIdentifier":"1955","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"890.pdf","filesize":[{"value":"152.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"890.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/710/files/890.pdf"},"version_id":"e049b70b-7141-41d2-9518-be7098516836"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Repeated immobilization stress increases uncoupling protein 1 expression and activity in Wistar rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Repeated immobilization stress increases uncoupling protein 1 expression and activity in Wistar rats","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-03-28"},"publish_date":"2008-03-28","publish_status":"0","recid":"710","relation_version_is_last":true,"title":["Repeated immobilization stress increases uncoupling protein 1 expression and activity in Wistar rats"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:23:42.446106+00:00"}