| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2008-03-28 |
| タイトル |
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タイトル |
Repeated immobilization stress increases uncoupling protein 1 expression and activity in Wistar rats |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
橋本, 眞明
Gao, B
Kikuchi-Utsumi, K
Ohinata, H
Kuroshima, A
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| 著者 ローマ字 |
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Hashimoto, Masaaki |
| 書誌情報 |
Japanese Journal of Physiology
巻 53,
号 3,
p. 205-213,
発行日 2003-06-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0021-521X |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.2170/jjphysiol.53.205 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.ncbi.nlm.nih.gov/pubmed?term=Repeated%20immobilization%20stress%20increases%20uncoupling%20protein%201%20expression%20and%20activity%20in%20Wistar%20rats | http://www.ncbi.nlm.nih.gov/pubmed?term=Repeated%20immobilization%20stress%20increases%20uncoupling%20protein%201%20expression%20and%20activity%20in%20Wistar%20rats |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Repeat immobilization-stressed rats are leaner and have improved cold tolerance due to enhancement of brown adipose tissue (BAT) thermogenesis. This process likely involves stress-induced sympathetic nervous system activation and adrenocortical hormone release, which dynamically enhances and suppresses uncoupling protein 1 (UCP1) function, respectively. To investigate whether repeated immobilization influences UCP1 thermogenic properties, we assessed UCP1 mRNA, protein expression, and activity (GDP binding) in BAT from immobilization-naïve or repeatedly immobilized rats (3 h daily for 4 weeks) and sham operated or adrenalectomized (ADX) rats. UCP1 properties were assessed before (basal) and after exposure to 3 h of acute immobilization. Basal levels of GDP binding and UCP1 expression was significantly increased (140 and 140%) in the repeated immobilized group. Acute immobilization increased GDP binding in both naïve (180%) and repeated immobilized groups (220%) without changing UCP1 expression. In ADX rats, basal GDP binding and UCP1 gene expression significantly increased (140 and 110%), and acute immobilization induced further increase. These data demonstrate that repeated immobilization resulted in enhanced UCP1 function, suggesting that enhanced BAT thermogenesis contributes to lower body weight gain through excess energy loss and an improved ability to maintain body temperature during cold exposure. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
The Physiological Society of Japan , Gao, Bihu ; Kikuchi-Utsumi, Kazue ; Ohinata, Hiroshi ; Hashimoto, Masaaki ; Kuroshima, Akihiro, Japanese Journal of Physiology, 53(3), 2003, 205-213.
\npublisher |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
VoR |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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14529581 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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3228 |
890.pdf (152.9 kB)
