{"created":"2023-06-19T11:20:38.417298+00:00","id":702,"links":{},"metadata":{"_buckets":{"deposit":"118a954c-0d33-4155-8dcd-c7a4bc7ba624"},"_deposit":{"created_by":3,"id":"702","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"702"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000702","sets":["7","7:23"]},"author_link":["1894","1895","1896","1897","1898"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"1486","bibliographicPageStart":"1483","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"Progress in Medicine"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"カルシウム拮抗薬アゼルニジピンの抗酸化作用について検討した.方法は,アゼルニジピン,アムロジピン,ニフェジピンの被検薬をストラップ剤としてPBNを用いたESR法により,生体内で発生する活性酸素で最も酸化力,細胞毒性が強いヒドロキシラジカルとの反応速度定数を比較した.その結果,ヒドロキシラジカルに対する二次反応定数はアゼルニジピン 1.1×10^10,アムロジピン 2.3×10^9,ニフェジピン 1.6×10^9の順となり,ヒドロキシラジカル消去能はアゼルニジピンがアムロジピンの約5倍の抗酸化能を有することが明らかにされた.以上のことから,アゼルニジピンは高い脂溶性を示し,効率よく細胞膜に分布することが予測され,虚血再灌流や炎症などで発生する活性酸素種から細胞膜を保護し,細胞障害を抑える可能性があると示唆された","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"出版社版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0287-3648","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2003304516"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1907"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"580"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Sumitomo, Kazuhiro"},{"subitem_text_language":"en","subitem_text_value":"Hasebe, Naoyuki"},{"subitem_text_language":"en","subitem_text_value":"Shishido, Naomi"},{"subitem_text_language":"en","subitem_text_value":"Nakamura, Masao"},{"subitem_text_language":"en","subitem_text_value":"Kikuchi, Kenjiro"},{"subitem_text_language":"en"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"住友, 和弘","creatorNameLang":"ja"},{"creatorName":"スミトモ, カズヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1894","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷部, 直幸","creatorNameLang":"ja"},{"creatorName":"ハセベ, ナオユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1895","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宍戸, 直美","creatorNameLang":"ja"},{"creatorName":"シシド, ナオミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1896","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村, 正雄","creatorNameLang":"ja"},{"creatorName":"ナカムラ, マサオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1897","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池, 健次郎","creatorNameLang":"ja"},{"creatorName":"キクチ, ケンジロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1898","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"878.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"878.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/702/files/878.pdf"},"version_id":"32a8a034-6012-4126-bfe4-531d6d4a2bad"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"カルシウム拮抗薬Azelnidipine(カルブロック)の抗酸化作用の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"カルシウム拮抗薬Azelnidipine(カルブロック)の抗酸化作用の検討","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"3","path":["6","7","23"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-03-17"},"publish_date":"2008-03-17","publish_status":"0","recid":"702","relation_version_is_last":true,"title":["カルシウム拮抗薬Azelnidipine(カルブロック)の抗酸化作用の検討"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-16T09:35:42.383518+00:00"}