{"created":"2023-06-19T11:20:36.542992+00:00","id":666,"links":{},"metadata":{"_buckets":{"deposit":"c3bc7f1d-44a0-4e7a-8ded-f816e14176a8"},"_deposit":{"created_by":3,"id":"666","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"666"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000666","sets":["7","7:24"]},"author_link":["1684","1685","1686"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"569","bibliographicPageStart":"565","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"Oncology Reports"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.ncbi.nlm.nih.gov/pubmed?term=Relationship%20between%20expression%20of%20matrix%20metalloproteinase-2%20and%20matrix%20metalloproteinase-9%20and%20invasion%20ability%20of%20cervical%20cancer%20cells | http://www.ncbi.nlm.nih.gov/pubmed?term=Relationship%20between%20expression%20of%20matrix%20metalloproteinase-2%20and%20matrix%20metalloproteinase-9%20and%20invasion%20ability%20of%20cervical%20cancer%20cells","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Constitutive overexpression of matrix metalloproteinases (MMPs) is frequently observed in malignant tumors. MMPs are a family of zinc endopeptidases consisting of at least 20 different members. In particular, MMP-2 and MMP-9 are reported to be closely associated with invasion and metastasis in several cancers. We investigated whether expression of MMP-2 and MMP-9 is associated with invasion ability of seven cervical cancer cells by administration of o-phenanthroline as MMP inhibitor. In two cell lines, Siha and Caski, MMP-2 mRNA and protein were expressed at high levels. After treatment with o-phenanthroline, the rate of invasion in these two cell lines was significantly decreased. In contrast, in the other two cell lines, HT-3 and Caski, high levels of MMP-9 mRNA and protein were expressed but there was no decrease in the rate of invasion in these cells after treatment with o-phenanthroline. The data suggest that expression level of MMP-2 mRNA may regulate with invasion ability of cervical cancer.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"D.A. Spandidos, Kato, Yasuhito ; Yamashita, Tsuyoshi ; Ishikawa, Mutsuo, Oncology Reports, 9(3), 2002, 565-569.\n\\npublisher","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1021-335X","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"11956628"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2827"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1703"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Kato, Yasuhito"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"加藤, 育民"},{"creatorName":"カトウ, ヤスヒト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1684","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamashita, T"}],"nameIdentifiers":[{"nameIdentifier":"1685","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, M"}],"nameIdentifiers":[{"nameIdentifier":"1686","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"839.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"839.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/666/files/839.pdf"},"version_id":"45a7f947-2dbf-471a-96e2-b532d2b4fc93"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Relationship between expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 and invasion ability of cervical cancer cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Relationship between expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 and invasion ability of cervical cancer cells","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-01-08"},"publish_date":"2008-01-08","publish_status":"0","recid":"666","relation_version_is_last":true,"title":["Relationship between expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 and invasion ability of cervical cancer cells"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:43:04.613785+00:00"}