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Relationship between expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 and invasion ability of cervical cancer cells
https://asahikawa-med.repo.nii.ac.jp/records/666
https://asahikawa-med.repo.nii.ac.jp/records/666415c8602-0d55-481a-817d-f409941ed2c6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
839.pdf (2.7 MB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||
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| 公開日 | 2008-01-08 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Relationship between expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 and invasion ability of cervical cancer cells | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
加藤, 育民
× 加藤, 育民
× Yamashita, T
× Ishikawa, M
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| 著者 ローマ字 | ||||||||||||||
| Kato, Yasuhito | ||||||||||||||
| 書誌情報 |
Oncology Reports 巻 9, 号 3, p. 565-569, 発行日 2002-05-01 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 1021-335X | |||||||||||||
| リンクURL | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | http://www.ncbi.nlm.nih.gov/pubmed?term=Relationship%20between%20expression%20of%20matrix%20metalloproteinase-2%20and%20matrix%20metalloproteinase-9%20and%20invasion%20ability%20of%20cervical%20cancer%20cells | http://www.ncbi.nlm.nih.gov/pubmed?term=Relationship%20between%20expression%20of%20matrix%20metalloproteinase-2%20and%20matrix%20metalloproteinase-9%20and%20invasion%20ability%20of%20cervical%20cancer%20cells | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Constitutive overexpression of matrix metalloproteinases (MMPs) is frequently observed in malignant tumors. MMPs are a family of zinc endopeptidases consisting of at least 20 different members. In particular, MMP-2 and MMP-9 are reported to be closely associated with invasion and metastasis in several cancers. We investigated whether expression of MMP-2 and MMP-9 is associated with invasion ability of seven cervical cancer cells by administration of o-phenanthroline as MMP inhibitor. In two cell lines, Siha and Caski, MMP-2 mRNA and protein were expressed at high levels. After treatment with o-phenanthroline, the rate of invasion in these two cell lines was significantly decreased. In contrast, in the other two cell lines, HT-3 and Caski, high levels of MMP-9 mRNA and protein were expressed but there was no decrease in the rate of invasion in these cells after treatment with o-phenanthroline. The data suggest that expression level of MMP-2 mRNA may regulate with invasion ability of cervical cancer. | |||||||||||||
| 注記 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 注記 | D.A. Spandidos, Kato, Yasuhito ; Yamashita, Tsuyoshi ; Ishikawa, Mutsuo, Oncology Reports, 9(3), 2002, 565-569. \npublisher |
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| 資源タイプ | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 資源タイプ | text | |||||||||||||
| 著者版フラグ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| フォーマット | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | application/pdf | |||||||||||||
| ID(XooNIps) | ||||||||||||||
| 11956628 | ||||||||||||||
| 閲覧数(XooNIps) | ||||||||||||||
| ダウンロード数(XooNIps) | ||||||||||||||
| 1703 | ||||||||||||||
