| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-12-03 |
| タイトル |
|
|
タイトル |
Oxidative damage to RNA in neurodegenerative diseases |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
布村, 明彦
Honda, K
Takeda, A
Hirai, K
Xiongwei, Zhu
Smith, MA
Perry, G
|
| 著者 ローマ字 |
|
|
|
Nunomura, Akihiko |
| 書誌情報 |
Journal of Biomedicine and Biotechnology
巻 2006,
p. 82323-1-82323-6,
発行日 2006-01-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1110-7243 |
| DOI |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1155/JBB/2006/82323 |
| リンクURL |
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|
内容記述タイプ |
Other |
|
内容記述 |
http://www.ncbi.nlm.nih.gov/pubmed/17047315 | http://www.ncbi.nlm.nih.gov/pubmed/17047315 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Since 1999, oxidative damage to RNA molecules has been described in several neurological diseases including Alzheimer's disease, Parkinson's disease, Down syndrome, dementia with Lewy bodies, prion disease, subacute sclerosing panencephalitis, and xeroderma pigmentosum. An early involvement of RNA oxidation of vulnerable neuronal population in the neurodegenerative diseases has been demonstrated, which is strongly supported by a recent observation of increased RNA oxidation in brains of subjects with mild cognitive impairment. Until recently, little is known about consequences and cellular handling of the RNA damage. However, increasing body of evidence suggests detrimental effects of the RNA damage in protein synthesis and the existence of several coping mechanisms including direct repair and avoiding the incorporation of the damaged ribonucleotides into translational machinery. Further investigations toward understanding of the consequences and cellular handling mechanisms of the oxidative RNA damage may provide significant insights into the pathogenesis and therapeutic strategies of the neurodegenerative diseases. |
| 注記 |
|
|
内容記述タイプ |
Other |
|
注記 |
Hindawi Publishing Corporation, Nunomura, Akihiko ; Honda, Kazuhiro ; Takeda, Atsushi ; Hirai, Keisuke ; Xiongwei, Zhu ; Smith, Mark A. ; Perry, George, Journal of Biomedicine and Biotechnology, 2006, 2006, 82323-1-82323-6.
\npublisher |
| 資源タイプ |
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|
内容記述タイプ |
Other |
|
資源タイプ |
text |
| フォーマット |
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|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
|
|
|
17047315 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
1560 |
812.pdf (178.7 kB)
