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Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review

https://asahikawa-med.repo.nii.ac.jp/records/650
https://asahikawa-med.repo.nii.ac.jp/records/650
876bedad-7037-472b-ad51-f1acd5972de2
名前 / ファイル ライセンス アクション
811.pdf 811.pdf (293.8 kB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2007-12-03
タイトル
タイトル Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review
言語 en
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 吉田, 貴彦

× 吉田, 貴彦

吉田, 貴彦

ja-Kana ヨシダ, タカヒコ

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Yamauchi, H

× Yamauchi, H

Yamauchi, H

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Fan, Sun Gui

× Fan, Sun Gui

Fan, Sun Gui

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著者 ローマ字
Yoshida, Takahiko
書誌情報 Toxicology & Applied Pharmacology

巻 198, 号 3, p. 243-252, 発行日 2004-08-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 0041-008X
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1016/j.taap.2003.10.022
リンクURL
内容記述タイプ Other
内容記述 http://www.sciencedirect.com/science/journal/0041008X | http://www.sciencedirect.com/science/journal/0041008X
抄録
内容記述タイプ Abstract
内容記述 Chronic arsenic (As) poisoning has become a worldwide public health issue. Most human As exposure occurs from consumption of drinking water containing high amounts of inorganic As (iAs). In this paper, epidemiological studies conducted on the dose–response relationships between iAs exposure via the drinking water and related adverse health effects are reviewed. Before the review, the methods for evaluation of the individual As exposure are summarized and classified into two types, that is, the methods depending on As concentration of the drinking water and the methods depending on biological monitoring for As exposure; certain methods may be applied as optimum As exposure indexes to study dose–response relationship based on various As exposure situation. Chronic effects of iAs exposure via drinking water include skin lesions, neurological effects, hypertension, peripheral vascular disease, cardiovascular disease, respiratory disease, diabetes mellitus, and malignancies including skin cancer. The skin is quite sensitive to arsenic, and skin lesions are some of the most common and earliest nonmalignant effects related to chronic As exposure. The increase of prevalence in the skin lesions has been observed even at the exposure levels in the range of 0.005–0.01 mg/l As in drinking waters. Skin, lung, bladder, kidney, liver, and uterus are considered as sites As-induced malignancies, and the skin is though to be perhaps the most sensitive site. Prospective studies in large area of endemic As poisoning, like Bangladesh or China, where the rate of malignancies is expected to increase within the next several decades, will help to clarify the dose–response relationship between As exposure levels and adverse health effects with enhanced accuracy.
注記
内容記述タイプ Other
注記 Academic Press, Yoshida, Takahiko ; Yamauchi, Hiroshi ; Fan Sun, Gui, Toxicology & Applied Pharmacology, 198(3), 2004, 243-252.
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資源タイプ text
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出版タイプ AM
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内容記述タイプ Other
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