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Porphyrin-induced photooxidation of conjugated bilirubin
https://asahikawa-med.repo.nii.ac.jp/records/644
https://asahikawa-med.repo.nii.ac.jp/records/6443f5de124-2802-4053-8e28-e18f1a1a9595
| 名前 / ファイル | ライセンス | アクション |
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805.pdf (303.1 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||
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| 公開日 | 2007-12-03 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Porphyrin-induced photooxidation of conjugated bilirubin | |||||||||||||
| 言語 | en | |||||||||||||
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| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
宍戸, 直美
× 宍戸, 直美
× Nakayama, K
× Nakamura, M
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| 著者 ローマ字 | ||||||||||||||
| Shishido, Naomi | ||||||||||||||
| 書誌情報 |
Free Radical Research 巻 37, 号 10, p. 1061-1067, 発行日 2003-10-01 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 1071-5762 | |||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | 10.1080/10715760310001600381 | |||||||||||||
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| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | http://www.ncbi.nlm.nih.gov/pubmed?term=Porphyrin-induced%20photooxidation%20of%20conjugated%20bilirubin | http://www.ncbi.nlm.nih.gov/pubmed?term=Porphyrin-induced%20photooxidation%20of%20conjugated%20bilirubin | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Visible light irradiation of 18 microM bilirubin ditaurate (BR-DT) at pH 7.0 for 30 min showed a 10% decrease in absorbance at 445 nm. When the reaction was carried out in the presence of a trace amount of uroporphyrin (UP), the spectrum of BR-DT disappeared without a concomitant formation of biliverdin. Photooxidation products were confirmed to be dipyrrole-containing compounds. Photo-bleaching of BR-DT was accelerated by the increasing concentration of UP and was inhibited, when UP was replaced by Cu2+UP. Formation of 2,2,6,6-tetramethylpiperidine N-oxyl through the irradiation of UP was diminished by sodium azide, a potent scavenger of singlet oxygen. The efficiency of singlet oxygen formation through visible light irradiation was in the order UP, coproporphyrin > Cu2+UP. Both bilirubin and BR-DT bound to human serum albumin (HAS) were photooxidized effectively in the presence of UP. The results indicate that irradiation of UP produces singlet oxygen with high efficiency which then rapidly oxidizes free and conjugated bilirubin. | |||||||||||||
| 注記 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 注記 | Taylor & Francis, Shishido, Naomi ; Nakayama, Kenji ; Nakamura, Masao, Free Radical Research, 37(10), 2003, 1061-1067. \nauthor |
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| 資源タイプ | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 資源タイプ | text | |||||||||||||
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| 出版タイプ | AM | |||||||||||||
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| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | application/pdf | |||||||||||||
| ID(XooNIps) | ||||||||||||||
| 14703795 | ||||||||||||||
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| ダウンロード数(XooNIps) | ||||||||||||||
| 840 | ||||||||||||||
