{"created":"2023-06-19T11:20:34.064755+00:00","id":616,"links":{},"metadata":{"_buckets":{"deposit":"5169303b-2d7c-4be3-af07-50806ceb8f9d"},"_deposit":{"created_by":3,"id":"616","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"616"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000616","sets":["7","7:24"]},"author_link":["1401","1402","1403","1404","1405","1406","1407","1408","1409","1410","1411","1412"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"355","bibliographicPageStart":"349","bibliographicVolumeNumber":"358","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/journal/0006291X | http://www.sciencedirect.com/science/journal/0006291X","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"α-Defensin is an antimicrobial peptide which plays an important role in innate immunity. Human defensin (HD)-5 is stored in the Paneth cells of the small intestine as a pro-form and is cleaved by trypsin, which is co-secreted from the Paneth cell granules. The mature HD-5 is protected from further digestion by the proteolysis enzyme. We generated both recombinant HD-5 and proHD-5, and the reduced form of each peptide in order to determine their physiological roles of the disulfide bonds. The reduced proHD-5 attenuated the bactericidal activity and the stability against the trypsin digestion. Human defensin was protected from the enzymatic degradation by disulfide bridges. We further purified the HD-5 with a disulfide variation in the small intestine of Crohn’s disease patients. The HD-5 was sensitive to the trypsin treatment. These observations evidently predict that a defensin deficiency may be caused by a disulfide disorder in the disease.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"Elsevier, Tanabe, Hiroki ; Ayabe, Tokiyoshi ; Maemoto, Atsuo ; Ishikawa, Chisato ; Inaba, Yuhei ; Sato, Ryu ; Moriichi, Kentaro ; Okamoto, Kotaro ; Watari, Jiro ; Kono, Toru ; Ashida, Toshifumi ; Kohgo, Yutaka, Biochemical and Biophysical Research Communications, 358(1), 2007, 349-335.\n\\nauthor","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2007.04.132","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"17482139"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"3007"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1499"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Tanabe, Hiroki"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田邉, 裕貴"},{"creatorName":"タナベ, ヒロキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1401","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ayabe, T"}],"nameIdentifiers":[{"nameIdentifier":"1402","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maemoto, A"}],"nameIdentifiers":[{"nameIdentifier":"1403","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, C"}],"nameIdentifiers":[{"nameIdentifier":"1404","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inabe, Y"}],"nameIdentifiers":[{"nameIdentifier":"1405","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, R"}],"nameIdentifiers":[{"nameIdentifier":"1406","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moriichi, K"}],"nameIdentifiers":[{"nameIdentifier":"1407","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okamoto, K"}],"nameIdentifiers":[{"nameIdentifier":"1408","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watari, J"}],"nameIdentifiers":[{"nameIdentifier":"1409","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kono, T"}],"nameIdentifiers":[{"nameIdentifier":"1410","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ashida, T"}],"nameIdentifiers":[{"nameIdentifier":"1411","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kohgo, Y"}],"nameIdentifiers":[{"nameIdentifier":"1412","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"773.pdf","filesize":[{"value":"4.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"773.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/616/files/773.pdf"},"version_id":"c86d2792-051d-4e87-b573-cc074e3a6aa3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-10-29"},"publish_date":"2007-10-29","publish_status":"0","recid":"616","relation_version_is_last":true,"title":["Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:20:18.676113+00:00"}