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Effects of macrolides on antigen presentation and cytokine production by dendritic cells and T lymphocytes
https://asahikawa-med.repo.nii.ac.jp/records/611
https://asahikawa-med.repo.nii.ac.jp/records/61173303f29-229f-4b43-9a0a-15ea178c9386
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
768.pdf (242.0 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||
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| 公開日 | 2007-10-29 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Effects of macrolides on antigen presentation and cytokine production by dendritic cells and T lymphocytes | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
石田, 芳也
× 石田, 芳也
× Abe, Y
× Harabuchi, Y
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| 著者 ローマ字 | ||||||||||||||
| Ishida, Yoshiya | ||||||||||||||
| 書誌情報 |
International Journal of Pediatric Otorhinolaryngology 巻 71, 号 2, p. 297-305, 発行日 2007-02-01 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 0165-5876 | |||||||||||||
| DOI | ||||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | 10.1016/j.ijporl.2006.10.016 | |||||||||||||
| リンクURL | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | http://www.sciencedirect.com/science/journal/01655876 | http://www.sciencedirect.com/science/journal/01655876 | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Macrolides are effective therapeutic agents for chronic respiratory tract diseases, such as chronic sinusitis, sinobronchial syndrome and diffuse panbronchiolitis. Although only limited information is available about their mechanisms, suppression of various inflammatory cytokines (IL-8, etc.) and some transcription factors has been reported to be involved. Non-typeable Haemophilus influenzae (NTHI) is one of the most important pathogens of the respiratory tract. P6 is one of the outer membrane proteins of NTHI and the target antigen of protective antibodies. To analyze the influence of macrolides on human dendritic cells (DCs), we treated DCs with macrolides and used them as antigen-presenting cells (APCs). Clarithromycin, roxithromycin and prednisolone suppressed the in vitro proliferative response of CD4+ T cells to P6 and also the production of cytokines. As a control, we also cultured DCs alone and exposed them to the medicament, while conversely culturing T cells without adding any drugs to the cultures. The results showed similar tendencies for suppression of immune responses. These findings suggest that macrolides suppress the antigen-specific immune responses of DCs in vitro. | |||||||||||||
| 注記 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 注記 | Elsevier, Ishida, Yoshiya ; Abe, Yusuke ; Harabuchi, Yasuaki, International Journal of Pediatric Otorhinolaryngology, 71(2), 2007, 297-305. \nauthor |
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| 資源タイプ | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 資源タイプ | text | |||||||||||||
| フォーマット | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | application/pdf | |||||||||||||
| ID(XooNIps) | ||||||||||||||
| 17137638 | ||||||||||||||
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| ダウンロード数(XooNIps) | ||||||||||||||
| 2478 | ||||||||||||||
