{"created":"2023-06-19T11:25:11.151599+00:00","id":6010,"links":{},"metadata":{"_buckets":{"deposit":"3e0f145f-179e-4743-998c-94d681720665"},"_deposit":{"created_by":1,"id":"6010","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"6010"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00006010","sets":["7","7:24"]},"author_link":["18962","18963","18961","18964"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"232","bibliographicPageStart":"230","bibliographicVolumeNumber":"137","bibliographic_titles":[{"bibliographic_title":"Journal of Pharmacological Sciences"}]}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID：29958814","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We hypothesized that the cannabinoid (CB) system may mediate the brain orexin- or ghrelin-induced visceral antinociception. Intraperitoneal injection of either CB1/2 agonist, WIN 55212 or O-Arachidonoyl ethanolamine increased the threshold volume of colonic distension-induced abdominal withdrawal reflex in rats, suggesting CB could induce visceral antinociception. Pretreatment with either the CB1 or CB2 antagonist potently blocked the centrally injected orexin-A-induced antinociceptive action against colonic distension while CB2 but not CB1 antagonist blocked the brain ghrelin-induced visceral antinociception. These results suggest that the cannabinoid signaling may be involved in the central orexin- or ghrelin-induced antinociceptive action in a different mechanistic manner.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/\nlicenses/by-nc-nd/4.0/)","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jphs.2018.06.001.","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-8613","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"29958814"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"336"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"303"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Okumura, Toshikatsu"},{"subitem_text_value":"Nozu, Tsukasa"},{"subitem_text_value":"Kumei, Shima"},{"subitem_text_value":"Ohhira, Masumi"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"奥村, 利勝"},{"creatorName":"オクムラ, トシカツ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18961","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野津, 司"},{"creatorName":"ノヅ, ツカサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18962","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"粂井, 志麻"},{"creatorName":"クメイ, シマ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18963","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大平, 賀子"},{"creatorName":"オオヒラ, マスミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18964","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"7139.pdf","filesize":[{"value":"467.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"7139.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/6010/files/7139.pdf"},"version_id":"968e3de9-200a-4dd8-90b9-771a86ac062a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cannabinoid","subitem_subject_scheme":"Other"},{"subitem_subject":"Neuropeptide","subitem_subject_scheme":"Other"},{"subitem_subject":"Visceral sensation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats"}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-12-03"},"publish_date":"2018-12-03","publish_status":"0","recid":"6010","relation_version_is_last":true,"title":["Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:05:10.150416+00:00"}