{"created":"2023-06-19T11:25:06.411799+00:00","id":5927,"links":{},"metadata":{"_buckets":{"deposit":"bc816343-0c8e-4efc-aea4-d8c4f5fa55dc"},"_deposit":{"created_by":1,"id":"5927","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5927"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005927","sets":["7","7:23"]},"author_link":["18647","18649","18650","18648","18651","18646","18652"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"250","bibliographicPageStart":"238","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"臨床リウマチ"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"目的:近年関節リウマチ(RA)患者の高齢化に伴い高齢RA患者に対しても生物学的製剤を使用する機会が増えている。エタネルセプト(ETN)は血中半減期の短さから、高齢関節リウマチ(RA)患者にも比較的安全に使用可能であると考えられ、既に多数例に使用されていると思われるが、その使用成績の報告は少ない。我々は75歳以上でETNを開始した高齢RA患者48名におけるETNの有効性と安全性を検討した。対象・方法:2008年5月から2014年3月に当院でETNを導入した336人のRA患者のうち、導入時の年齢が75歳以上であった48例(男性18例、女性30例)を対象に、24ヵ月を最終評価時として、患者背景、疾患活動性の推移、有害事象をretrospectiveに解析した。結果:患者の平均年齢は79.0±2.9歳で、ETN使用により関節所見、血清学的所見、疾患活動性スコアはいずれも有意に改善を認め、使用前に比べ最終評価時ではプレドニゾロン(PSL)の平均使用量も有意に少なかった。有害事象は11例に認め、7例でETNの使用が中止され、そのうち4例は感染症であった。結核(85歳)、ニューモシスチス肺炎(80歳)による死亡を各1例ずつ認めた。結論:75歳以上の高齢RA患者において、ETNは重篤な感染症については注意が必要であるが、有効な治療手段であると考えられた。","subitem_description_type":"Abstract"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.14961/cra.29.238","subitem_relation_type_select":"DOI"}}]},"item_5_relation_27":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2018160784","subitem_relation_type_select":"ICHUSHI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0914-8760","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2018160784"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"512"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"410"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Kodama, Satoru"},{"subitem_text_value":"Ito, Satoshi"},{"subitem_text_value":"Kobayashi, Daisuke"},{"subitem_text_value":"Narita, Ichiei"},{"subitem_text_value":"Murasawa, Akira"},{"subitem_text_value":"Makino, Yuichi"},{"subitem_text_value":"Nakazono, Kiyoshi"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"児玉, 暁"},{"creatorName":"コダマ, サトル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18646","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 聡"},{"creatorName":"イトウ, サトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18647","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林, 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