{"created":"2023-06-19T11:25:05.494167+00:00","id":5907,"links":{},"metadata":{"_buckets":{"deposit":"8de0294c-017e-4f44-a5f1-43720c32de0f"},"_deposit":{"created_by":1,"id":"5907","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5907"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005907","sets":["7","7:24"]},"author_link":["18536","18537","18535","18533","18531","18528","18534","18529","18532","18530"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageStart":"1010428317711311","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Tumor Biology"}]}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID：28639907","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ferrichrome is known to be a siderophore, but it was recently identified as a tumor-suppressive molecule derived from Lactobacillus casei ATCC334 ( L. casei). In the present study, we investigated the effects of ferrichrome in gastric cancer cells. Cell lines and xenograft models treated with ferrichrome demonstrated growth suppression. The expression levels of cleaved poly (adenosine diphosphate-ribose) polymerase, and cleaved caspase-9 were increased by ferrichrome treatment. Although the tumor-suppressive effects of ferrichrome were almost completely diminished by the iron chelation, the reduction in the intracellular iron by ferrichrome did not correlate with its tumor-suppressive effects. An exhaustive docking simulation indicated that iron-free ferrichrome can make stable conformations with various mammalian molecules, including transporters and receptors. In conclusion, probiotic-derived ferrichrome induced apoptosis in gastric cancer cells. The iron binding site of ferrichrome is the structure responsible for its tumor suppressive function.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/)","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1177/1010428317711311.","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1010-4283","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"28639907"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"467"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"682"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Ijiri, Masami"},{"subitem_text_value":"Fujiya, Mikihiro"},{"subitem_text_value":"Konishi, Hiroaki"},{"subitem_text_value":"Tanaka, Hiroki"},{"subitem_text_value":"Ueno, Nobuhiro"},{"subitem_text_value":"Kashima, Shin"},{"subitem_text_value":"Moriichi, Kentaro"},{"subitem_text_value":"Sasajima, Junpei"},{"subitem_text_value":"Ikuta, Katsuya"},{"subitem_text_value":"Okumura, Toshikatsu"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井尻, 学見"},{"creatorName":"イジリ, マサミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18528","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤谷, 幹浩"},{"creatorName":"フジヤ, ミキヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18529","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西, 弘晃"},{"creatorName":"コニシ, ヒロアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18530","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 宏樹"},{"creatorName":"タナカ, ヒロキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18531","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野, 伸展"},{"creatorName":"ウエノ, ノブヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18532","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"嘉島, 伸"},{"creatorName":"カシマ, シン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18533","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"盛一, 健太郎"},{"creatorName":"モリイチ, ケンタロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18534","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笹島, 順平"},{"creatorName":"ササジマ, ジュンペイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18535","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生田, 克哉"},{"creatorName":"イクタ, カツヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18536","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"奥村, 利勝"},{"creatorName":"オクムラ, トシカツ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18537","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"7016.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"7016.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5907/files/7016.pdf"},"version_id":"9d45e646-7e9c-401a-9afc-0f0dae9521f2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"DNA damage-inducible transcript 3","subitem_subject_scheme":"Other"},{"subitem_subject":"Gastric cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-tumor","subitem_subject_scheme":"Other"},{"subitem_subject":"anticancer","subitem_subject_scheme":"Other"},{"subitem_subject":"c-Jun N-terminal kinase","subitem_subject_scheme":"Other"},{"subitem_subject":"ferrichrome","subitem_subject_scheme":"Other"},{"subitem_subject":"iron binding","subitem_subject_scheme":"Other"},{"subitem_subject":"iron chelation","subitem_subject_scheme":"Other"},{"subitem_subject":"probiotics","subitem_subject_scheme":"Other"},{"subitem_subject":"siderophores","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Ferrichrome identified from Lactobacillus casei ATCC334 induces apoptosis through its iron-binding site in gastric cancer cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ferrichrome identified from Lactobacillus casei ATCC334 induces apoptosis through its iron-binding site in gastric cancer cells."}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-11"},"publish_date":"2018-06-11","publish_status":"0","recid":"5907","relation_version_is_last":true,"title":["Ferrichrome identified from Lactobacillus casei ATCC334 induces apoptosis through its iron-binding site in gastric cancer cells."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:08:32.905053+00:00"}