{"created":"2023-06-19T11:25:04.289680+00:00","id":5884,"links":{},"metadata":{"_buckets":{"deposit":"46af1b6b-b040-40a4-adc4-189fcd66bd55"},"_deposit":{"created_by":3,"id":"5884","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5884"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005884","sets":["7","7:27:41"]},"author_link":["18394"],"item_10_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ムスカリン性アセチルコリン受容体によるJNKの活性化はマウス腸管における分泌を負に制御する"}]},"item_10_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"153","bibliographicPageStart":"150","bibliographicVolumeNumber":"127","bibliographic_titles":[{"bibliographic_title":"Journal of pharmacological sciences"}]}]},"item_10_degree_grantor_32":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"旭川医科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"10107","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10_degree_name_31":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_10_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID：25704031","subitem_description_type":"Other"}]},"item_10_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Regulation of intestinal secretion is important for body fluid homeostasis. We investigated the role of three MAP kinases (MAPKs) as negative regulators in muscarinic cholinoceptor (mAChR)-mediated intestinal secretion in mice. Electrophysiological analyses revealed that mAChR stimulation enhanced intestinal chloride secretion, which was further augmented by the inhibition of JNK but not by that of ERK or p38 with specific inhibitors SP600125, U0126 or SB203580, respectively. Immunoblot analyses in colonic mucosa showed that mAChR stimulation increased MAPKs phosphorylation that was suppressed by the specific inhibitor for each MAPK. This suggests that JNK is a major negative regulator in mAChR-induced intestinal secretion.","subitem_description_type":"Abstract"}]},"item_10_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).","subitem_description_type":"Other"}]},"item_10_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10_dissertation_number_29":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲524"}]},"item_10_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jphs.2014.10.001","subitem_relation_type_select":"DOI"}}]},"item_10_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-8613","subitem_source_identifier_type":"ISSN"}]},"item_10_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Md., Tariqul  Islam","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18394","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6981.pdf","filesize":[{"value":"909.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6981.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5884/files/6981.pdf"},"version_id":"341953cc-a91e-48ff-bffb-961103ba528d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Intestinal secretion","subitem_subject_scheme":"Other"},{"subitem_subject":"MAP kinase","subitem_subject_scheme":"Other"},{"subitem_subject":"mAChR","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Muscarinic cholinoceptor-mediated activation of JNK negatively regulates intestinal secretion in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Muscarinic cholinoceptor-mediated activation of JNK negatively regulates intestinal secretion in mice","subitem_title_language":"en"}]},"item_type_id":"10","owner":"3","path":["6","7","41"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-03-29"},"publish_date":"2018-03-29","publish_status":"0","recid":"5884","relation_version_is_last":true,"title":["Muscarinic cholinoceptor-mediated activation of JNK negatively regulates intestinal secretion in mice"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-09T06:59:08.164378+00:00"}