{"created":"2023-06-19T11:24:55.138255+00:00","id":5709,"links":{},"metadata":{"_buckets":{"deposit":"877eb1a0-9f28-483a-a3e7-22ae1ec43407"},"_deposit":{"created_by":1,"id":"5709","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5709"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005709","sets":["7","7:24"]},"author_link":["17868","17859","17869","17858","17865","17864","17866","17862","17861","17867","17863","17860"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"181","bibliographicPageStart":"175","bibliographicVolumeNumber":"104","bibliographic_titles":[{"bibliographic_title":"International journal of hematology"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://link.springer.com/article/10.1007%2Fs12185-016-2002-6 | https://link.springer.com/article/10.1007%2Fs12185-016-2002-6","subitem_description_type":"Other"}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID：27086349","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Non-Tf-bound iron (NTBI), which appears in serum in iron overload, is thought to contribute to organ damage; the monitoring of serum NTBI levels may therefore be clinically useful in iron-overloaded patients. However, NTBI quantification methods remain complex, limiting their use in clinical practice. To overcome the technical difficulties often encountered, we recently developed a novel automated NTBI quantification system capable of measuring large numbers of samples. In the present study, we investigated the in vivo behavior of NTBI in human and animal serum using this newly established automated system. Average NTBI in healthy volunteers was 0.44 ± 0.076 μM (median 0.45 μM, range 0.28-0.66 μM), with no significant difference between sexes. Additionally, serum NTBI rapidly increased after iron loading, followed by a sudden disappearance. NTBI levels also decreased in inflammation. The results indicate that NTBI is a unique marker of iron metabolism, unlike other markers of iron metabolism, such as serum ferritin. Our new automated NTBI quantification method may help to reveal the clinical significance of NTBI and contribute to our understanding of iron overload.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The final publication is available at Springer via http://dx.doi.org/10.1007/s12185-016-2002-6.","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s12185-016-2002-6.","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0925-5710","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"27086349"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"476"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"433"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Ito, Satoshi"},{"subitem_text_value":"Ikuta, Katsuya"},{"subitem_text_value":"Kato, Daisuke"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"Niizeki, Noriyasu"},{"subitem_text_value":"Toki, Yasumichi"},{"subitem_text_value":"Hatayama, Mayumi"},{"subitem_text_value":"Yamamoto, Masayo"},{"subitem_text_value":"Shindo, Motohiro"},{"subitem_text_value":"Iizuka, Naomi"},{"subitem_text_value":"Kohgo, Yutaka"},{"subitem_text_value":"Fujiya, Mikihiro"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊藤, 巧"},{"creatorName":"イトウ, サトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17858","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生田, 克哉"},{"creatorName":"イクタ, カツヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤, 大介"},{"creatorName":"カトウ, ダイスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17860","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Addo, Lynda"}],"nameIdentifiers":[{"nameIdentifier":"17861","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"新関, 紀康"},{"creatorName":"ニイゼキ, ノリヤス","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17862","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"土岐, 康通"},{"creatorName":"トキ, ヤスミチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17863","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"畑山, 真弓"},{"creatorName":"ハタヤマ, マユミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17864","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本, 昌代"},{"creatorName":"ヤマモト, マサヨ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17865","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"進藤, 基博"},{"creatorName":"シンドウ, モトヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17866","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"飯塚, 直美"},{"creatorName":"イイヅカ, ナオミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17867","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高後, 裕"},{"creatorName":"コウゴ, ユタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17868","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤谷, 幹浩"},{"creatorName":"フジヤ, 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(NTBI)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"In vivo behavior of NTBI revealed by automated quantification system.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In vivo behavior of NTBI revealed by automated quantification system."}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-06-12"},"publish_date":"2017-06-12","publish_status":"0","recid":"5709","relation_version_is_last":true,"title":["In vivo behavior of NTBI revealed by automated quantification system."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:14:43.742471+00:00"}